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Which NVAF patients are candidates for TSOACs ?

Which NVAF patients are candidates for TSOACs ?. Compelling candidates Have NVAF and meet CHADS 2 or CHA 2 DS 2 VASc criteria for anticoagulation AND ≥1 of the following Poor INR control in spite of good compliance with warfarin Unusual difficulty with regular INR checks

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Which NVAF patients are candidates for TSOACs ?

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  1. Which NVAF patients are candidates for TSOACs? • Compelling candidates • Have NVAF and meet CHADS2 or CHA2DS2VASc criteria for anticoagulation AND ≥1 of the following • Poor INR control in spite of good compliance with warfarin • Unusual difficulty with regular INR checks • True warfarin allergy • Understand potential disadvantages (e.g. lack of antidote) and are willing to trade them for convenience of no lab monitoring • Less compelling candidates • Have indications other than NVAF for anticoagulation (e.g. mechanical heart valve) or an unacceptable risk-benefit ratio for warfarin use • Are stable on warfarin with TTR > 72% • Have CrCl < 30 ml/min • Have poor INR control due to poor compliance • Potential financial barriers to care (e.g. no prescription benefit coverage) • Other questionable characteristics • Age ≥ 75 yoa • History of cardiac disease • History of GI bleed

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