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Embryology of the Reproductive Organs. The entire process of sexual development depends on a sequential series of interactions between regulatory factors and genetic machinery . Stages of Sexual Determination (Differentiation). Chromosomal Determination XX or XY
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Embryology of the Reproductive Organs The entire process of sexual development depends on a sequential series of interactions between regulatory factors and genetic machinery.
Stages of Sexual Determination (Differentiation) • Chromosomal Determination XX or XY • Gonadal Determination Ovary or testes • Phenotypic determination What do sex organs look like
1. Chromosomal Determination Ovum 22 Autosomes 1 X chromosome Sperm 22 Autosomes 1 X chromosome or 1 Y chromosome Zygote = 46 XX or 46 XY
Primordial Germ Cells Genital/GonadalRidge At Six Weeks
Testes Determining Factor TDF is a gene on the Y chromosome that converts the Gonadal/Genital ridge to a testes Inside a testes you have: • Seminiferous tubules – Spermatogonia inside • Sertoli cells – Produces MIF (Mullerian inhibiting Factor in embryo. • Interstitial cells – Produce Testosterone
Mullerian Duct Gonadal Ridge Wolffian Duct
Gonadal Ridge Mullerian Duct Wolffian Duct
Epidydidimis Vas deferens Degenerating Mullerian Duct Seminal Vesicle
Ovaries Fallopian Tubes Uterus Upper Part of Vagina
Undifferentiated external Genital tubercle Genital groove Genital fold Labioscrotal swelling
Undifferentiated external Genital Tubercle Labioscrotal Swelling Genital Fold Genital Groove
Undifferentiated Stage Genital Tubercle Genital Fold Genital Groove Labioscrotal Swelling
Genital Tubercle Genital Fold Genital Groove Labioscrotal Swelling Glans Penis Penile Rafe Urethra Scrotal Sac
Genital Tubercle Genital Fold Genital Groove Labioscrotal Swelling Clitoris Labia Minor Vaginal and Urethral Opening Labia Major
Transabdominal movement Formation of the Inguinal Canal Movement into scrotal sac
Gubernaculum • Phallus • Inguinal Canal • Testes • Abdominal cavity • Vas deferens
Masculanize the Wolffian Duct Testosterone