Learning Objectives

1. On the CUSP: STOP BSI Using the Centers for Disease Control and Prevention’s National Healthcare Safety Network (NHSN) for CLABSI Surveillance in Adult ICUs

2. Learning Objectives • To review the NHSN definition of a central line • To review the NHSN definition of bloodstream infection (BSI) • To review the NHSN denominator definition for calculating CLABSI rates in adult ICUs

3. What is a Central Line? • An intravascular catheter that terminates at or close to the heart or in one of the great vessels which is used for infusion, withdrawal of blood, or hemodynamic monitoring. • Great vessel: aorta, pulmonary artery, superior vena cava, inferior vena cava, brachiocephalic veins, internal jugular veins, subclavian veins, external iliac veins, and common femoral veins • Infusion: introduction of a solution through a blood vessel via a catheter lumen • The location of the insertion site and type of device are NOT relevant

4. Pacemakers Implanted cardiac defibrillators Radial, dorsalis pedis, brachialis, ulnar arterial lines What is a Central Line? • Non-tunneled central lines • Tunneled central lines • Introducers • Implanted ports • Hemodialysis catheters • Peripherally inserted central catheters (PICCs) • Femoral artery catheter The following are examples of central lines, as long as they terminate at or close to the heart or in one of the great vessels NOTE: This list is not inclusive The following are examples of devices that are not central lines NOTE: This list is not inclusive

5. Data That Need to Be Collected • For determining CLABSI rate • Numerator: number of CLABSIs • Denominator: number of central line-days • Expressed as a rate of X CLABSI/1,000 central line days • #CLABSI/# central line days X 1000 • For determining the Central Line Utilization Ratio • Numerator: number of central line-days • Denominator: number of patient-days

6. The Numerator

7. Definition of BSI in Adults Criterion 1: • Patient has a recognized pathogen cultured from one or more blood cultures AND • Organism cultured from blood is not related to an infection at another site.

8. Definition of BSI in Adults • Criterion 2: • Patient has at least one of the following signs or symptoms: fever (>38oC), chills, or hypotension • AND • Signs and symptoms and positive laboratory results not related to an infection at another site • AND • Common skin contaminant is cultured from two or more blood cultures drawn on separate occasions. • Blood from ≥ 2 blood draws collected within 2 days

9. S. aureus Enterococcus spp. E. coli Pseudomonas spp. Klebsiella spp. Enterobacter spp. Citrobacter spp. Serratia marcescens Acinetobacter spp. Candida spp. Microbiology • Diphtheroids: Corynebacterium spp. • Bacillus spp. • Not B. anthracis • Propionibacterium spp. • Coagulase-negative staphylococci • Including S. epidermidis • Viridans group streptococci • Aerococcus spp. • Micrococcus spp. Examples of Common Recognized Pathogens (not inclusive) Examples of Common Skin Contaminants (not inclusive)

10. When Are Organisms the Same? • If isolates are identified to the species level in one culture, and with only a descriptive name (i.e., to the genus level) from the other culture • If isolates are speciated but no antibiograms are done or done for only one of the isolates

11. When Are Organisms Not the Same? • If isolates have different antibiograms for two or more antimicrobial agents • For the purpose of NHSN antibiogram reporting, the category interpretation of intermediate (I) should NOT be used to distinguish whether two organisms are different

12. Timing of CLABSI • Central line-associated BSI • A central line was in place at the time of onset of the event OR • A central line was in place within 48 hours before onset of the event • There is no minimum period of time that the central line must be in place in order for the BSI to be considered central line-associated

13. Location of Attribution • The patient care area where the event became evident • CLABSIs in patients with central lines placed in non-inpatient areas (emergency department, operating room) are attributed to the inpatient unit • Transfer Rule: If a CLABSI develops within 48 hours of transfer from one inpatient location to another in the same facility, the infection is attributed to the transferring location

14. Entering Numerator Data • The Primary Bloodstream Infection (BSI) Form (CDC 57.108) is used to collect and report each CLABSI that is identified during the month • Other data requested • Specific criteria met for identifying the primary BSI • Whether the patient died • Causative organisms • Organisms’ antimicrobial susceptibilities.

15. The Denominator

16. Collecting Central Line Days • For ICUs, the number of patients with one or more central lines of any type is collected daily, at the same time each day, and then summed • The total is reported for the month on the Denominators for Intensive Care Unit (ICU)/Other Locations (Not NICU or Specialty Care Area (SCA)) (CDC 57.118).

17. Collecting Central Line Days: Multiple Lines in an ICU Patient • If a patient has more than one central line (permanent or temporary) on a given day, count the day as only one central line day.

18. Action Items • Verify that the infection control group in your institution is collecting CLABSI rates based on the NHSN definitions for what is a central line and what is a BSI • Verify that both catheters days and patient days are being collected correctly in the ICU(s)

19. References • National Healthcare Safety Network (NHSN): Device-Associated (DA) Module • www.cdc.gov/nhsn/psc_da.html