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Development of B lymphocytes

Development of B lymphocytes. Parham, Chapter 4. B cell development. Fig. 4.2. antigen-independent. pre-B cell. immature B cell. mature B cell. stem cell. (. m. chain +). (IgM +). (IgM. +. , IgD +). antigen-dependent. IgM. isotype switching. IgG. IgE. IgA.

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Development of B lymphocytes

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  1. Development of B lymphocytes Parham, Chapter 4 H. HogenEsch, 2004

  2. B cell development Fig. 4.2 H. HogenEsch, 2004

  3. antigen-independent pre-B cell immature B cell mature B cell stem cell ( m chain +) (IgM +) (IgM + , IgD +) antigen-dependent IgM isotype switching IgG IgE IgA H. HogenEsch, 2004

  4. Pre-B cell pre-B cell receptor = m + surrogate light chain H. HogenEsch, 2004

  5. B cell development in bone marrow H. HogenEsch, 2004 Bone marrow stromal cells

  6. Ig gene rearrangements – allelic exclusion H. HogenEsch, 2004 Fig. 4.6

  7. Sequential L chain gene segment rearrangements H. HogenEsch, 2004

  8. Immunoglobulin gene expression during B cell development H. HogenEsch, 2004

  9. Selection of immature B cells Fig. 4.13 H. HogenEsch, 2004

  10. Receptor editing H. HogenEsch, 2004

  11. B-1 cells vs. B-2 cells H. HogenEsch, 2004

  12. B-1 cells vs. B-2 cells (cont’d) H. HogenEsch, 2004

  13. X-linked agammaglobulinemia • Recurrent infections of extracellular bacteria • Recessive, X-linked • Defect in Bruton’s tyrosine kinase • Nearly complete absence of circulating immunoglobulins • Reduced number of pre-B cells in bone marrow, lack of mature B cells • Normal thymus and normal number of T cells H. HogenEsch, 2004

  14. Circulation of naïve B cells Fig. 4.15 H. HogenEsch, 2004

  15. Further development of mature B cells H. HogenEsch, 2004

  16. Effect of specific antigen on B cell migration and differentiation Fig. 4.16 H. HogenEsch, 2004

  17. M = mantle zone • GC = germinal center • D = dark zone • L = light zone Histology of the lymph node cortex H. HogenEsch, 2004

  18. apoptosis apoptosis B cell life cycle days - weeks Naïve B cell Ag 5 days IgM paracortex medulla months bone marrow IgG isotype switching germinal center memory B cell H. HogenEsch, 2004

  19. B cell tumors H. HogenEsch, 2004

  20. Burkitt’s lymphoma H. HogenEsch, 2004

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