Development and survival of lymphocytes

Aug 19, 2012

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Development and survival of lymphocytes

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Lymphocyte development and survival Chapter 7

Lymphocyte development and survival Chapter 7. Objectives. Describe or construct flow charts showing the stages in development of B cells and T cells, including: The general characteristics (surface markers, etc) of lymphocytes at each stage

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Clonal Diversification of Lymphocytes

Clonal Diversification of Lymphocytes. Review of last lecture. Whereas Mature T cells proliferate when they contact antigens. Whenever immature pre-T Cells recognize self-antigens, they are programmed to auto-destruct in the Thymus. Thymus. Bone Marrow .

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T LYMPHOCYTES

بسم الله الرحمن الرحيم. T LYMPHOCYTES. Dr. Shaikh Mujeeb Ahmed Assistant professor Physiology Al Maarefa College . T (thymic) Lymphocytes. Lymphocytes migrate from bone marrow to the thymus for preprocessing to form “T” lymphocytes Preprocessing in the thymus :

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1. Surface markers on T lymphocytes and their function 2. Subsets of T lymphocytes 3. Function of T lymphocytes

T lymphocytes. 1. Surface markers on T lymphocytes and their function 2. Subsets of T lymphocytes 3. Function of T lymphocytes. T cells are composed of a group of functionally different and heterogeneous lymphocytes. They are so called because they differentiate and mature in thymus.

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Lymphocytes

Lymphocytes. Play major role in immunity GENESIS 1.Lymphoblast :15-20 micrometer Large nucleus with rarely more than 2 distinct nucleoli Cytoplasm is blue as a narrow rim around the large nucleus. Prolymphocyte :. Prolymphocyte : Cell and nucleus become smaller,

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B lymphocytes

B lymphocytes. J. Ochotná. B- lymphocytes. B- cells recognize native antigen through BCR (B cell receptor)

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Lymphocytes and Immunity

Lymphocytes and Immunity. Clinical Pathology Ms. Canga. Reading Assignment. A&P book: pp. 237 – 246 Lab Pro book: pp. 45, & 48-49 (There are some very helpful pictures on these pages as well!). Lymphocytes…. …are the predominant WBC in ___________ and ___________.

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Lymphocytes

Lymphocytes. When mature, they have Immunocompetence ; they are able to _ Self-tolerance unresponsive to self antigens Naive (unexposed) B and T cells are exported to lymph nodes, spleen, and other lymphoid organs. T Cells.

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Development of B lymphocytes

Development of B lymphocytes. Parham, Chapter 4. B cell development. Fig. 4.2. antigen-independent. pre-B cell. immature B cell. mature B cell. stem cell. (. m. chain +). (IgM +). (IgM. +. , IgD +). antigen-dependent. IgM. isotype switching. IgG. IgE. IgA.

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T lymphocytes

T lymphocytes. Contents. 1. Surface markers on T lymphocytes and their function 2. Subsets of T lymphocytes 3. Function of T lymphocytes.

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Lymphocytes

Lymphocytes. Methods to Obtain Non-coagulating Blood - Heparin (5-10 IU/ml): activates antithrombin III, blocks the action of thrombin - EDTA: binds Ca2+ - Citrate: binds Ca2+. The most important CD antigens of lymphocytes. Marker: Cell Subpopulation CD3 , CD4, CD8 T-lymfocytes

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The development of lymphocytes

Ch8. The development of lymphocytes. Immune system. Design for living. Boundary. Self/non-self recognition. Ags………. Innate immunity. Germline-encoded receptors. Adaptive immunity. Gene rearranged receptors: TCR/BCR. Lymphopoiesis. B/T cell development. Cells

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Poetry of/and Survival

Poetry of/and Survival. HUM 3285: British and American Literature Spring 2011 Dr. Perdigao March 14, 2011. In Memoriam. Robert Lowell, Jr. (1917-1977) Born in Boston, attended Harvard (1935-7) but completed education at Kenyon College in Ohio in 1940

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Lecture 8 The Development of Lymphocytes

Lecture 8 The Development of Lymphocytes. Core content. Students should know:. T cell receptor gene rearrangement and lineage commitment preTCR Positive selection Negative selection Changes in surface phenotype during T cell maturation in thymus.

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Chapter 7 The Development and Survival of Lymphocytes

Chapter 7 The Development and Survival of Lymphocytes. Most of this chapter is about the maturation/development of lymphocytes in the absence of foreign antigen (from pre-lymphocyte to mature naïve lymphocyte):. Gene rearrangements

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Antigen Receptors of Lymphocytes

Antigen Receptors of Lymphocytes. Receptors for recognition. Innate immunity. Recognition: molecular patterns. Genes: functional, germline encoded. Presence: multiple copies of different receptors. Distribution: non-clonal distribution

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Lymphocytes and Immunity

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T -lymphocytes

T -lymphocytes. T cell receptor T – cytotoxic (CD8) cells T – helper (CD4) cells Activation of T cells. T cell receptor. Alpha and beta polypeptide chains Antigen - major histocompatibility (MHC) binding site. Figure 16.15 – two different T cell receptors. Figure 16.16 MHC molecules.

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The Power of Research and Development-Evolution, Adaptation, and Survival

Businesses, like all other organisms, have to adapt to the meet the changing needs of their environment, namely, the markets they serve. If organisations fail to evolve, sooner or later, they will fail to survive. For businesses, research and development is akin to the processes of natural selection that exist within the world of nature, allowing life to survive, adapt, and to flourish.

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