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Presented by Andrew Jackson

An Examination of the Role of the CKR5 ∆32 Allele in HIV Infection. A Brief Discussion on Table 2. as presented in: Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene.

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Presented by Andrew Jackson

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  1. An Examination of the Role of the CKR5∆32 Allele in HIV Infection A Brief Discussion on Table 2. as presented in: Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene Michael Dean, * Mary Carrington, * Cheryl Winkler, Gavin A. Huttley, Michael W. Smith, Rando Allikmets, James J. Goedert, Susan P. Buchbinder, Eric Vittinghoff, Edward Gomperts, Sharyne Donfield, David Vlahov, Richard Kaslow, Alfred Saah, Charles Rinaldo, Roger Detels, Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study, Stephen J. O'Brien Presented by Andrew Jackson

  2. The story behind CKR5? • CKR5 is a chemokine receptor which is present on the cell membrane of CD4+ T cells • CKR5 functions as a secondary receptor on CD4+ T lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). • The beta-chemokines MIP-1α, MIP-1β and RANTES inhibit infection of CD4+ T cells by HIV-1 as they can also bind to the chemoreceptor CKR5 • The CKR5 gene along with its close relative CKR1 gene has been mapped to chromosome 3p21,

  3. What about mutations of the CKR5 gene? Eight molecular genetic variants were identified by Dean et. al (1996). However only one mutation, a 32-base pair (bp) deletion (CKR5 Δ32 ) which causes a frame shift at amino acid 185 was significant The CKR5 Δ32 occurred in approximately 10 % of study cohort, the other seven variants we found were in less than 1% of the individuals studied .

  4. Is there a difference in the CKR5 genotype distribution between HIV-1 infected and uninfectedindividuals? This figure was constructed using the data for all six cohorts examined in Table 2. of Science, Dean et al. 273 (5283): 1856

  5. Conclusion There was a significant difference in the CKR5 genotype distribution between HIV-1 infected and uninfected individuals examined Of the individuals tested those which were homozygotes for the CKR5∆32, 17 in total, were all HIV-1 antibody negative This suggests that the CKR5∆32 allele is a recessive gene which offers phenotypic resistance to HIV-1 infection and antibody production

  6. Reference Dean M., M.Carrington, * C.l Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, and R. Detels. 1996.Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science (5283):1856-1862.

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