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Department of Anatomy, Physiology and Biochemistry

Solutions from veterinary medicine transferred to human health care. From boxers to babies. Katja Höglund. Department of Anatomy, Physiology and Biochemistry. Evaluation of heart murmurs. From: The science and practice of pediatric cardiology, 1998. Innocent or pathologic?.

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Department of Anatomy, Physiology and Biochemistry

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  1. Solutions from veterinary medicine transferred to human health care From boxers to babies Katja Höglund Department of Anatomy, Physiology and Biochemistry

  2. Evaluation of heart murmurs From: The science and practice of pediatric cardiology, 1998 Innocent or pathologic? Digital analysis of cardiac acoustic signals in children Milad El-Segaier. Thesis 2007

  3. Heart murmurs in boxer dogs Children Heart murmurs Heart disease 50-80% 1%

  4. Echocardiographic examination

  5. No heart disease Aortic stenosis

  6. Phonocardiographic examination

  7. Digital heart sound analysis Time-frequency properties Murmur duration >200 Hz Separation of innocent murmurs from murmurs caused by mild heart disease Murmur complexity (T2) Significantly higher in dogs with heart disease compared to dogs with innocent murmurs.

  8. Complexity (T2) vs. duration > 200 Hz Sensitivity94 % Specificity82 % = dogs with heart disease * = dogs with innocent murmurs

  9. Conclusions Duration of murmur frequency > 200 Hz can be used for differentiation between dogs with mild heart disease and dogs with innocent murmurs. Combining murmur duration with complexity analysis (T2) may be a useful method to diagnose heart disease in dogs. Höglund K, Ahlstrom C, Häggström J et al. Am J Vet Res. 2007 Sep;68(9):962-9 Höglund K. Systolic ejection murmurs and the left ventricular outflow tract in boxer dogs. Physiology and clinical evaluation. Thesis 2007. Assessing the severity of aortic stenosis using sample entropy of the phonocardiographic signal Ahlstrom C, Höglund K, Hult P et al. Submitted

  10. Digital heart sound analyses for assessment of severity of heart murmurs caused by mitral valve disease Ingrid Ljungvall, PhD-project Ongoing study

  11. Future implications Digital heart sound analyses are promising techniques for clinical evaluation of heart murmurs. This could be beneficial both for dogs and humans. The study team Katja Höglund, SLU, Uppsala Clarence Kvart, SLU, Uppsala Jens Häggström, SLU, Uppsala Ingrid Ljungvall, SLU, Uppsala Christer Ahlström, Linköping University Per Ask, Linköping University Peter Hult, Linköping University

  12. Thanks for your interest! Contact: Katja.Hoglund@afb.slu.se

  13. Group denomination paper III

  14. Indexed stroke volume (ml/m2) Indexed cardiac output (ml/min/m2)

  15. Clinical evaluation of heart murmurs Cardiac auscultation

  16. AA=aortic arch

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