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Learn about the three layers of the skin, their cell types, and functions. Understand the structures and functions of hair follicles, sweat glands, sebaceous glands, and nails. Discover how the skin protects, senses, regulates body temperature, and maintains fluid balance.
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The Integumentary System Instructor: Shahnaz pouladi Bushehr Medical Science University Nursing and Midwifery Faculty
Three Layers of skin: Epidermis: Stratified squamous epithelium; outer layer is "keratinized" or "cornified" Dermis: Dense irregular connective tissue Hypodermis: Adipose connective tissue (technically not part of system)
Epidermis:Avascular. Depends on blood vessels in underlying dermis for its nutrition Cells formed by mitosis in deepest, or basal layer, then get pushed into more superficial layers or "strata"
(Epidermis) Stratum Basale = Single row of dividing cells Stratum Spinosum = Three or four layers of cells; Some cell division Stratum Granulosum = Three or four layers of cells; Actively synthesizing protein keratin Stratum Lucidum = One or two layers of dying cells Stratum Corneum = Many layers of flat, dead, scale-like cells full of keratin
Primary cell type in epidermis = keratinocytes which produce large amounts of protein keratin Other cell types: Melanocytes produce pigment melanin & transfer it to keratinocytes Langerhans cells(really macrophages) clean up debris Merkel cells detect touch and pressure; transfer this information to sensory receptors in the dermis
Dermis: Dense irregular connective tissue Separated from epidermis (stratified squamous epithelium) by basement membrane Highly vascular Highly innervated Two Layers: Papillary layer just below epidermis Reticular layer forms deep 80%
Dermis = Dense irregular connective tissue. Thus: Cells = Fibroblasts / Fibrocytes Macrophages Mast cells Lymphocytes etc. Fibers = Collagen (therefore strong, flexible) Elastic (therefore stretchable) Weight gain tears collagen fibers producing striae (stretch marks)
Hypoderm (Subcutaneous Tissue) • Primarily is adipose tissue • Provides a cushion
Appendages of the skin Hair follicles and hair Sweat glands Sebaceous (oil) glands Nails on fingers and toes
Hair - Distribuled over all skin except: palms of hands soles of feet nipples glans of penis & clitoris minor labia - Formed in follicles located deep in dermis - Consists of layers of dead, highly keratinized keratinocytes
Shaft Root Bulb
Each hair is associated with: One or more sebacious (oil) glands An arrector pili muscle A plexus of nerves around the root
Hair • The rate of growth varies • Hair loss • Hair growth by sex hormone • Different functions of hairs • Hair color • Hair quantity and distribution • 3 phase: Anagen (2-6 year, growth phase)- Katagen( 2-3 weeks, transfer phase )- Telogen (2-3 month, Resting phase)
Nails: - Tips of fingers and toes - Thick layer of densely packed keratinocytes - Produced by nail matrixat proximal end, hidden under eponychium or cuticle Average growth: 0.5 mm per week
Sebaceous (oil) glands: - Branched tubular glands - Duct opens into opening of hair follicle - Secretes sebum, consisting of lipids, proteins, carbohydrates,
Sweat Glands - 2 to 3 million - Two types: Merocrine: Distributed over all skin except nipples (Eccrine) Simple coiled glands in dermis Duct leads to sweat pore on surface Secreted watery sweat for cooling Apocrine: Located only in axillary, pubic, anal regions Larger than eccrine glands Duct opens into opening of hair follicle Secretes thicker sweat, high content of proteins and fats.
Sweat is usually 99% water with a pH between 4 and 6 Sweat glands produce 500ml of insensible perspiration (no noticable wetness)daily Two specially modified sweat glands: Ceruminous—found in the external ear canal. Secretion combines with sebum and dead epidermal cells to form earwax (keeps eardrum pliable, canal waterproof and has a bactericidal effect) Mammary --milk producing glands found in the female breast (modified apocrine glands)
Functions of the skin • 1. Protection • First line of defense • Keratin: protects body from water loss, barrier for environmental factors (stratum corneum) • Melanin: keeps UV rays from penetrating • Surface film: sweat, oil, etc • Basal layer: composed of collagen(tissue organization and regeneration, selective permeability, physical barrier, bind)
Functions of the skin • 2. Sensation • Pressure, touch, temp, pain, etc • Two specialized receptors: • Meissner corpuscle – detects light pressure • Pacinian corpuscle – detects deep pressure
Functions of the skin • 3. Fluid balance • The stratum corneum has the capacity to absorb water • Skin damage (burn) • The skin is not completely impermeable to water. (evaporation) 600cc/day
Functions of the skin • 4. Body temperature • Body produces heat (metabolism of foods) • Body releases 80% of heat through skin • Three major physical processes for loss of heat [radiation, conduction (evaporation), convection]. • On a hot day the skin releases almost 3000 calories of body heat (enough to boil five gallons of water) • Heat loss is controlled by negative feedback loop • Skin blood flow
Functions of the skin • 3. Produces Vitamin D • Uv rays combine with skin to make cholecalciferol • Cholecalciferol is transported to the liver and kidneys where it is changed to vit D • Vitamin D is essential for preventing osteoprosis
Functions of the skin • Immune response function • Langerhans cells facilitate the uptake of IgE- associated allergens • Plays a pivotal role in the pathogenesis of atopic dermatitis and other allergic disease
Preparation • Equipment • Well-lit Room • Comfortable Environment • Hand washing • Appropriate use of Gloves • Privacy/Draping • Organized Assessment • Explanations
Physical Assessment • Inspection • Color • Bleeding • Ecchymosis • Vascularity • Lesions
Physical Assessment • Palpation • Moisture • Temperature • Texture • Turgor • Edema
Color • Normal=Uniformed whitish pink or brown • Abnormal • Cyanosis • Jaundice • Carotenemia • Albinism • Vitiligo
Physical Assessment • Bleeding, Ecchymosis, Vascularity • Normal=No areas • Abnormal • Spontaneous Bleeding • Petechiae • Ecchymosis • Venous Star • Necrosis
Lesions • Lesions • Normal=No lesions except freckles, birthmarks, nevi (flat moles) • Abnormal • Rashes • Pressure Ulcers • Burns
Kind of lesions in dermatology1- Primary Skin Lesions2-Secondary Skin Lesions