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History of Varian HPLC

History of Varian HPLC. Frankie Button HPLC Instrument Manager, Europe Region 1 November 2007. 1966 is where it all started……. 1966 – LC Research and Development Group of Varian was formed LC Development and Innovation took place every 1 to 3 years.

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History of Varian HPLC

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  1. History of VarianHPLC Frankie Button HPLC Instrument Manager, Europe Region 1 November 2007

  2. 1966 is where it all started…….. • 1966 – LC Research and Development Group of Varian was formed • LC Development and Innovation took place every 1 to 3 years. • In the early years this was mainly by product development • In later years this has been mainly by acquisition

  3. History of Varian HPLC Products • 1967 – Model 4000 Gas Displacement Pump and Micro-adsorption detector (MAD)

  4. History of Varian HPLC Products • 1968 – Varian purchased LC Division of Picker-Nuclear (Dedicated Nucleotide Analyzer, LCS-1000, 254 nm UV detector. • 1971 – Model 4200 Gradient Elution Chromatograph (syringe pump), Variscan Scanning UV Detector (Techtron – Melbourne)

  5. History of Varian HPLC Products • 1974 - Model 8500 HPLC syringe pump, RI detector, 8000 AutoSampler for HPLC, CDS 101

  6. History of Varian HPLC Products • 1976 – Varichrom Variable Wavelength UV-Vis detector (Cary) • 2nd Generation CDS System, with system control!

  7. History of Varian HPLC Products • 1977 – Fluorichrom filter fluorimeter

  8. History of Varian HPLC Products • 5000 series HPLC pump, major step forward • 5010 Isocratic analog pump • 5020 Binary gradient computer controller • 5030 Isocratic computer controller • UV-1 254 detector

  9. History of Varian HPLC Products • Inside the 5020

  10. History of Varian HPLC Products • 1979 – UV-50 UV-Vis detector • 1980 – vista 54/56 HPLC (Controlled by Vista 401 chromatography data station) 5060 Ternary gradient HPLC pump

  11. History of Varian HPLC Products • 1981 – Post Column Reactor, RI-3 (refractive index detector from LDC) • 1982 – UV-100 time programmable UV-Vis detector with fast HPLC option! • 1983 – 5560 HPLC, scanning UV-200 detector, • 8085 integrated AutoSampler, CDS-402 for control

  12. History of Varian HPLC Products • 1984 – 9090 low loss variable volume AutoSampler, 2010 Isocratic pump, 2020 Gradient controller, 2050 Programmable UV-Vis detector, 2070 Monochrometer based Fluorescence detector (all from Jasco)

  13. History of Varian HPLC Products • 1985 – PolyChrom 9060 Diode Array Detector, AASP Automated solid phase extraction system • ( Online SPE!!!)

  14. History of Varian HPLC Products • 1986 – CM-1 conductivity detector (OEM), DS-604 GPC calculation software • 1987 – RI-4 (OEM from ERC in Japan), 2500 Isocratic pump, 2502 Isocratic pump and gradient controller, 2550 time programmable UV-Vis detector (Jasco)

  15. History of Varian HPLC Products 1988 – Star 9010 ternary gradient pump, 9050 time programmable UV-Vis detector, 9095 High Performance AutoSampler, 9065 Diode Array detector, 9020 Windows based HPLC workstation

  16. History of Varian HPLC Products • 1989 – LC Workstation Rev C, SP-99 column oven (Spark Holland) • 1990 – 3D View for PolyView, PCR carbamate system (Pickering), 9001 Isocratic pump, Marathon AutoSampler (Spark Holland) • 1991 – 9070 Fluorescence Detector (Linear, Spectra Physics, Thermo), 9100 Cooled AutoSampler • 1992 – MCA for PolyView • 1993 – 9012/9002 extended flow range pumps, Mistral oven (Spark Holland), Electric 9100

  17. History of Varian HPLC Products • 1994 – Workstation version 4.0 (LC and GC combined), PolyView 4.0 (IsoView), 9300 AutoSampler (Spark Holland), Prospekt Automated solid phase extraction (Spark Holland)

  18. History of Varian HPLC Products • 1995 – Star 9080 Electrochemical detector ( Antec), Star 9040 RI detector (ERC), Star control of 9200 and 9300 • 1996 – 9025 Automation panel, LC/NMR, 9012 Quaternary pump, 9075 fluorescence detector (Thermo) • 1997 – Varian buys Rainin – SD-200/300, SD-1, UV-1, UV-C, UV-D, PDA-2, AI-1A, AI-96, AI-03, RamPak, ISCO FC-1, ISCO, FC-4

  19. History of Varian HPLC Products • 1998 – ProStar product line ( combines Rainin and Varian products), ProStar 330 Photodiode Array (Hitachi) PolyView 2000 • 1999 – ProStar 500 CVM, Helix system • 2000 – ProStar 363 Fluorescence detector, Varian buys Van Kel, Varian buys R&S, 520 Oven

  20. History of Varian HPLC Products • 2001 – PrepStar SD-2, PrepStar 530, Responder software, Helix 364 Fluorescence software, Star Reviewer for dHPLC, Polaris Educational systems • 2003 – ProStar 325 UV/Vis detector

  21. Key technical advances for Varian HPLC • Variscan - scanning UV-Vis detector 1971 • 5000 pump – single piston single pump ternary gradient system 1978 • Vista 401 – 4 channel, control LC and GC, dual high speed printers, replot with baseline, raw data storage 1980 • UV 100 – No RI high performance analytical product 1982 • PolyChrom 9060 PDA with mathematical evaluation of purity – 1985 • Star Workstation – Windows based data system, 1988 • PolyView spectral processing software – 1988 (MCA 1992) • SD-1 – the Waters alliance before there was an alliance – 1991 with Rainin. (A fire truck without the wheels) • ProStar 500 CVM – The ultimate in valving capability – 1999

  22. Varian products that lasted • 5000 pump deign – now in ProStar 230 • Vista 401 capabilities – now in Star and Galaxie • UV-100 design – Obsolete in 2003 by ProStar 325 • Spectral processing software – never surpassed!

  23. Products that customers loved • LC 5000 – many are still working today • Star 9010/9012/230 – same as above • Vista 401 – Incredible innovation and very easy to use • UV-100/9050/ProStar 310 – they were the workhorses of the lab • SD-1 – Unparalleled Performance • SD-200/SD-300/210/218 – the best in world for analytical to small scale prep

  24. HPLC at Varian for over 40 Years • Varian have always been, and always will be an Innovator in HPLC • Even in the last 10 years we have produced product after product, and several acquisitions • Over $8M Invested in the last 4 years to put us back on the HPLC Map • This new Era starts with, because it’s the first of many NEW HPLC products:

  25. The Future……….. • iHPLC

  26. Concept of the iHPLC 1st Fully Integrated HPLC System Easy to use, install and MAINTAIN Compact and Stylish in Design Complementary to part of existing modular line A Major step forward in performance and ergonomics and User Experience Single part numbers, easier to sell 26

  27. iHPLC • Two New Models • Analytical • Analytical to Prep

  28. iHPLC Analytical Concept: One Power Button One Power Cable One Communication cable …Whilst retaining the Self maintenance features Pre-plumbed and “Ready” out of the box Sample tray accessible without opening doors 28

  29. iHPLC Analytical USP: High Performance Analytical System Can be Optimised easily for good Fast LC performance The “First COMPLETE Integrated Solution” Simplicity in a one Box Simple to Install…Simple to Use....Simple to Maintain Neat, Compact and Stylish product 29

  30. iHPLC Analytical Consists of: NEW Pumps NEW Autosampler NEW Detectors Existing UV/DAD Detectors in an Integrated format 30

  31. iHPLC Analytical USP: The Only complete range of High Performance Information Rich LC Detectors IMS Software for simple user diagnostics, OQ and Service Storage space for LC Columns, Fittings and Tubing Tray Space for Columns, manual, tools, Software CD etc… 31

  32. iHPLC Analytical to Prep Consists of: Existing 210/218 Pumps in several integrated configurations NEW Fraction Collector NEW Prep Autosampler NEW Module for Column and Solvent Selection Existing UV/DAD Detectors in an Integrated format 32

  33. iHPLC Analytical to Prep Concept: One Power Button/Cable One Communication cable Easy interchangeability of components to retain flexibility Pre-plumbed and “Ready” out of the box 33

  34. iHPLC Analytical to Prep USP: High Performance Analytical System High Performance “Analytical to Prep” System High Performance Prep System The “Only COMPLETE Integrated Solution” Accepted Hardware 34

  35. iHPLC Analytical to Prep USP: Simple to Install…Simple to Use....Simple to Maintain Neat, Compact and Stylish product Modern, Stylish Fraction Collector…That works! Simple FC programming and manual intervention New Switching module concept, stylish design 35

  36. Galaxie Driver Awesome interface Very “Easy on the eye” –shockwave technology Simple to use An enormous step forward Installation configurator – simple to install 36

  37. Other Highlights Solvent tray capacity “Ski Slopes” for sample tray insertion/removal Single waste port Easy access for servicing/tubing and fitting replacement Leak detector 37

  38. Other Highlights Modern Manual Injectors – push button Bottle Management Software Tool Tips – makes everything easy Online Help and Videos “ Cary Style” Excellent Brochures – hoorah a brochure!!!!!!! New Data Sheets/Price Lists and App Notes 38

  39. Positioning Form part of our New LC range Still have modular options – very important Rebranded XXX-LC, eliminate ProStar name First product 356-LC Refractive Index plus 210/218/325/335etc.. New Grey “ Barbie Showers” 39

  40. Positioning Integrated Systems(iHPLC) Standard popular configurations New Format Modular Systems(XXX-LC) Low cost systems Odd configurations Biocompatible Online SPE Prep 2 Process/Flash LC GPC Systems Analytical Semi-Prep Prep Process GPC Flash Turnkey Custom EXCELLENT AND COMPREHENSIVE RANGE OF CONSUMABLES 40

  41. Conclusion Compact and Stylish Integrated Systems Retain flexibility and maintenance features Excellent hardware performance Excellent User Interface – pleasant experience Simple to Install Fits the topical “Fast LC” Model using our Two Brand NEW Small Particle LC Columns 41

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