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Processed Amniotic Membrane Allografts

Processed Amniotic Membrane Allografts. Amniotic Membrane Allografts. What is Human Amniotic Membrane?. A unique, avascular membrane separating the mother from the fetus. Provides an incubating environment promoting cellular differentiation.

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Processed Amniotic Membrane Allografts

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  1. Processed Amniotic Membrane Allografts

  2. Amniotic Membrane Allografts

  3. What is Human Amniotic Membrane? • A unique, avascular membrane separating the mother from the fetus. • Provides an incubating environment promoting cellular differentiation. • Provides an immunological barrier to prevent “foreign body” rejection. Photo: Courtesy of Juan Batlle, M.D.

  4. Anatomical Profile: AM

  5. Anatomy of the Ocular Surface (1) Conjunctival Epithelium (2) Corneal Epithelium (6) Limbus – Stem Cells

  6. History of AM in Ophthalmology • De Rotth. conjunctival defects (1940). • Lavery. lime burn of conjunctiva and cornea (1946). • Sorsbyet al. caustic soda burns (1947). • ALLOTRANSPLANTAT [late 80’s USSR->Venezuela, DR] • Batlle and Perdomo. Conjunctival substitute with placental allotransplant. Scientific Poster 25. American Academy of Ophthalmology meeting. Chicago, IL USA. October 1993. • Kim and Tseng. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 14:473-84, 1995. [

  7. Surgical Indications: AM • Pterygium Excision • Corneal Ulcerations/Perforations • Chemical/Thermal Burns • Bullous Keratopathy • Ocular Dermoids/Tumors • Fornix Reconstruction/Symblepharon • Stem Cell Transplants

  8. Pterygium • A mutated growth on the surface of the eye • Requires surgical excision and placement of graft

  9. Corneal Ulcerations/Perforations • A break or defect in corneal epithelium • Often secondary to other systemic diseases.

  10. Chemical/Thermal Burns • Chemical burns often caused by alkali • Potentially devastating trauma to surface of the eye • Limbal graft possibly indicated

  11. Bullous Keratopathy • Edema of the corneal endothelium • Very common and usually affects individuals over 50 years of age.

  12. Dermoid/Tumor Removal • Benign congenital tumors containing foreign tissue • Commonly found at the limbus

  13. Fornix Reconstruction • Fibrous tract that connects bulbar conj to conj of eyelid • Secondary to other acquired or traumatic conditions • Required reconstruction of ocular surface and eyelids

  14. Photo: Courtesy of Juan Batlle, M.D. Surgical Techniques: AMT/Pterygium

  15. AmbioDry2 Overview • Tested & Safe • Dehydrated • Terminally Sterilized • Strict, quality-controlled protocols • Device-like quality

  16. AmbioDry: Safe & Viable • Intact epithelial cell layer • Intact dense connective, basement membrane • Presence of loose fibroblast network

  17. AmbioDry: Logistical Features • Storage: Room-temp • No freezer required • No dry ice shipments • Simple prep: No soaks or rinses • IOP Customer Service: 24 Hrs/7 Days

  18. AmbioDry: Surgical Advantages • Substrate-free • Dry-state handling & trimming • Visual orientation identification • No tears or buttonholes • Device-like tissue quality

  19. AmbioDry Configurations • 1 x 2 cm • 2 x 3 cm • 4 x 4 cm

  20. Reimbursement Codes Supply Code: V2790 CPT Code: 65780 Ocular surface reconstruction; amniotic membrane transplantation

  21. AmbioDry & Tisseel The sutureless approach to eye surgery. Fibrin (biological) adhesive Eliminates sutures Reduces surgical time Improved patient care Better healing

  22. AmbioDry & Tisseel Video

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