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INFRAIA Project Kick-off Meeting Adrien Dartiguelongue, Bernard Ponsard

Join Adrien Dartiguelongue and Bernard Ponsard at the kick-off meeting of the INFRAIA Project. Learn about SCK•CEN, a leading research institute in Belgium, and their focus on the development and production of medical radioisotopes and radiopharmaceuticals. Explore their state-of-the-art facilities for radiolabeling, molecular synthesis, radiochemistry, and pre-clinical evaluation. Discover the potential involvement of SCK•CEN in irradiating targets, mass separation, radiochemical processing, and the production of new radiopharmaceuticals. Don't miss this exciting opportunity!

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INFRAIA Project Kick-off Meeting Adrien Dartiguelongue, Bernard Ponsard

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  1. INFRAIA Project Kick-off Meeting Adrien Dartiguelongue, Bernard Ponsard adrien.dartiguelongue@sckcen.be 30/04/2019

  2. SCK•CEN • Foundation of public utility, created in 1952, operating under tutorship of Belgian Minister of Energy • 2017: 49% governmental support, 51% self-financing (contract work) • Nuclear R&D, applications, energy development in Belgium • One of the largest research institutes in Belgium • 2017: 820 employees (36% with academic degree), 87 PhD students www.sckcen.be

  3. BR2 • The BR2 reactor is a 100 MW Material Test Reactor providing high thermal and fast neutron fluxes: • up to 1015 n/cm2s thermal neutrons • up to 6 x 1014n/cm2 s fast neutrons (above 100 keV) • Major facility for global routine supply of medical radioisotopes:Mo-99/Tc-99m, I-131, Xe-133, Lu-177, Ir-192, Re-186, Tb-161, Sm-153, Er-169, Y-90, P-32, W-188/Re-188, I-125, Sr-89, Sn-117m, ...

  4. NURA NURA Strategic program at SCK•CEN focusing on development and production of medical radioisotopes and radiopharmaceuticals From the reactor… • Radiolabeling • Molecular synthesis lab: chelators, linkers • Radiopharmacy labs: labeling, stability • Isotope production • Radiochemical labs with preparative HPLC, LLE setups… • Analytical services:αandγ spectrometry, ICP-MS… • Pre-clinical evaluation • Hot Animal Facility:in vitro (affinity, cytotoxicity) and in vivo imaging …to the radiopharmaceuticals

  5. Potential involvement of SCK•CEN Irradiation of targets in BR2 to produce high-potential radioisotopes: Sm-153, Tb-161, Er-169 Mass separation at ISOLDE/MEDICIS to obtain collected samples of Sm-153, Er-169 Radiochemical processing of targets and collected samples to produce non-carrier added Sm-153, Er-169, Tb-161 Radiolabeling and pre-clinical analysis of new radiopharmaceuticals

  6. Tb-IRMA-V • Production of Tb isotopes in ISOL facilities Separation of Tb from Gd irradiation matrix through selective oxidation Development of Tb radiolabeled radiopharmaceuticals

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