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Pol b FEN1 APE1

+. +. +. +. +. +. +. Figure 4. Genome instabilit y. Genome instability. APE1/ ANPG. Progression. Progression. APC mutated. Pol b FEN1 APE1. AID - mediated d e methylation of gene promoters. Transcription of several genes. TDG/MBD4. TP53 mut ated.

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Pol b FEN1 APE1

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  1. + + + + + + + Figure 4 Genome instability Genome instability APE1/ ANPG Progression Progression APC mutated Pol b FEN1 APE1 AID-mediated demethylation of gene promoters Transcription of several genes TDG/MBD4 TP53 mutated Transcription of Myc-regulated genes Angiogenesis Erythropoesis Proliferation Progression HIF-1a OGG1

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