1 / 17

Immunity: Part II

Immunity: Part II. WBCs. Internal Defenses of Innate Immunity ~White Blood Cells~. If invaders actually get within the body, then your white blood cells (WBCs) begin their attack WBCs circulate throughout the blood, using the bloodstream to get from one organ to another. Video. WBCs.

helga
Download Presentation

Immunity: Part II

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Immunity: Part II WBCs

  2. Internal Defenses of Innate Immunity~White Blood Cells~ • If invaders actually get within the body, then your white blood cells (WBCs) begin their attack • WBCs circulate throughout the blood, using the bloodstream to get from one organ to another. Video

  3. WBCs • aka. Leukocytes • Form from generalized stem cells in bone marrow • Hemocytoblasts (ALL blood cells and platelets stem from these cells) • Lack hemoglobin • Defend the body

  4. Phagocytes: 1st Line of Cellular Defense Microphages – neutrophils & eosinophils Macrophages – derived from monocytes

  5. Microphages • Leave the bloodstream and enter peripheral tissues subjected to injury or infection

  6. The monocyte-macrophage system • aka: the reticuloendothelial system

  7. Macrophages • Actively phagocytic cells derived from circulating monocytes. • Almost every tissue in the body shelters macrophages.

  8. Macrophages • Fixed – resident macrophages in body tissue • Ex: microglia in CNS • Ex: Kupffer cells in and around blood vessels in the liver • Free – visiting macrophages in body tissues • Move into and through • Diffuse

  9. ~All Phagocytes~ • WBCs are responsible for eating foreign particles by engulfing them • Once engulfed, the phagocyte breaks the foreign particles apart in organelles called ________ Lysosomes

  10. Pseudopodia surround microbes. 1 Microbes Microbes are engulfed into cell. 2 MACROPHAGE Vacuole containing microbes forms. 3 Vacuole Lysosome containing enzymes Vacuole and lysosome fuse. 4 Toxic compounds and lysosomal enzymes destroy microbes. 5 Microbial debris is released by exocytosis. 6 Phagocytic Cells • Phagocytes attach to their prey via surface receptors • And engulf them, forming a vacuole that fuses with a lysosome

  11. ~All Phagocytes~ Diapedesis Chemotaxis http://www.nature.com/nature/journal/v404/n6774/fig_tab/404135a0_F1.html http://www.nature.com/nature/journal/v404/n6774/fig_tab/404135a0_F1.html

More Related