CNS, CSF Flow Models, and Systemic Simulations

1. CNS, CSF Flow Models, and Systemic Simulations March 3, 2011 Loren Kim Mentor: Cierra M. Hall Advisor: Professor Linninger Laboratory for Product and Process Design Department of Bioengineering University of Illinois, Chicago, IL

2. Topics: • Systemic Flow Model Simulations of 4 Species • CNS model *Revisions • CSF model • Connection of the CSF flow model to the CNS model • Connection of the CNS flow model to the systemic flow model

3. Systemic Flow Model Simulations • Performed and validated simulations for 4 species Hagen Poiseuille's Equation:

4. Systemic Flow Modeling Simulations

5. Systemic Flow Model Simulations

6. CNS model *Revisions • Addition of the right and left brachiocephalic veins • Connection of the Sphenoparietal Sinus • Revisiting the Willis Circle • Removal of unnecessary arteries and veins connecting to the spinal capillaries

7. CSF Model

8. Connection of CSF and CNS

9. Systemic Flow Modeling

10. Goals: • Finish revising the CNS model • Run simulations on the CNS and CSF model • Connect the models • Start the research paper: Introduction and Methods

11. Questions?