1 / 19

CSF Flow in Chiari I and Syringomyelia

CSF Flow in Chiari I and Syringomyelia. From the perspective of Computational Fluid Dynamics. Karen H. Støverud , K.-A. Mardal , V. Haughton , H.P. Langtangen Bologna, Oct . 6, 2010. This presentation aims to describe how abnormal CSF flow can affect the spinal cord.

sahara
Download Presentation

CSF Flow in Chiari I and Syringomyelia

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CSF Flow in Chiari I and Syringomyelia From theperspectiveof Computational Fluid Dynamics Karen H. Støverud, K.-A. Mardal, V. Haughton, H.P. Langtangen Bologna, Oct. 6, 2010

  2. This presentation aims to describe how abnormal CSF flow can affect the spinal cord Why do Chiaripatientsdevelopsyringomyelia? • Oscillatory CSF flow • Measurements • Simulations • Consequencesofabnormal CSF flowonthe spinal cord • Simulations

  3. CSF flowvaries throughout the cardiac cycle, in relation with changing pressure gradients Systole Diastole

  4. The goal of PCMR is to identify patients that will benefit from surgery Major abnormalities Minor abnormalities • Limits: • Inaccuratevelocities • Low temporal resolution

  5. Today, computationalmodelsare used throughout all industries …but to a littleextent in medicine…

  6. To gain a better insight of cyclic CSF flow and pressures, computational models are powerful tools. MRI + Computer Models = Optimal Treatment

  7. CSF flow in thesubarachnoidspacesimulated by a computationalmodel: Complexflow: • Jets • Bidirectionalflow • Greaterflowanteriorthanposterior • Variationalongthe spinal axis Linge et al. 2010

  8. Magnitude offlowvariesboth in theaxial and sagittal plane Geometries Velocityprofiles Roldan et al. 2009

  9. Greaterpressure gradients have beenobserved in Chiaripatientsthan in normals Steeperpressure gradient in regions ofnarrowed SAS Roldan et al. 2009

  10. Simulationsof CSF flow have beenvalidated by themeansof PC MRI Shah et al. 2009

  11. Computer models have improved the understanding of CSF flow and pressure in the subarachnoid space • Models • 3D • Velocity • Pressure • PCMR • 2D • Velocity CSF flow is characterized by: Jets Bidirectionalflow Greaterflowanteriorthanposterior to thecord. Pressure gradient

  12. Investigatingtheeffectsofabnormalpressure gradients onthe spinal cordtissue Spinal cord tissue as a poro-elastic medium:

  13. We created an idealized model of the spinal cord and prescribed the pressure in the surrounding CSF

  14. Fluid enters the spinal cord in regions of high pressure and leaves in regions of low pressure

  15. Fluid accumulate in the spinal cordwhen a centralcanalwithhighpermeability is added

  16. The spinal cordcontractswherethepressure is high and expandswherethepressure is low Blue: Tissuecontracts Orange: Tissue expands presyrinx develops

  17. In conclusion, computational modelsmayincreaseourunderstandingof CSF flow and syrinxformation • Volume (3D) display of velocity and pressure • Greater spatial and temporal resolution • Demonstrates increased jets and bidirectional flow in Chiari • Demonstrates steeper pressure gradients in Chiari • Including the central canal fluid accumulate in the spinal cord • Predicts presyrinx state

More Related