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The Time Has Come to Analyze DNA Profile Databases

The Time Has Come to Analyze DNA Profile Databases. Dan E. Krane, Ph.D., Wright State University, Dayton, OH. Forensic Bioinformatics (www.bioforensics.com). National DNA Index System (NDIS). Established in 1994, controlled by the FBI.

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The Time Has Come to Analyze DNA Profile Databases

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  1. The Time Has Come to Analyze DNA Profile Databases Dan E. Krane, Ph.D., Wright State University, Dayton, OH Forensic Bioinformatics (www.bioforensics.com)

  2. National DNA Index System (NDIS) • Established in 1994, controlled by the FBI. • Explicit expectation that records would be subject to research and quality control. • No published research derived from NDIS to date.

  3. Benefits of analyses of anonymized records • Quality assurance/quality control • Potential for improved search strategies • Potential for refinements of test kits • Evaluation of population genetic assumptions used for statistical weights • Use of real-world data in place of simulations

  4. Review of Victoria State Database Krane/Paoletti analysis: >11,000 profiles each compared to all others across 9 loci: Shared allelesObserved occurrences 14401 1527 161 1716 18 0 AussieBump

  5. 300 100 20 1

  6. Benefits of analyses of anonymized records • Quality assurance/quality control • Potential for improved search strategies • Potential for refinements of test kits • Evaluation of population genetic assumptions used for statistical weights • Use of real-world data in place of simulations

  7. Benefits of analyses of anonymized records • Quality assurance/quality control • Evaluation of population genetic assumptions used for statistical weights • Are populations uniform at city/state/region/nation levels? • Are similar close relatives common? • Use of real-world data in place of simulations

  8. How would you determine the frequency of Obama supporters in Seattle? Obama WA 61.2% ? Popular vote in 2012 by Congressional district. Romney won red districts, Obama won blue districts.

  9. How would you determine the frequency of Obama supporters in Seattle? Obama WA 61.2% Region 60.6% ? Popular vote in 2012 by Congressional district. Romney won red districts, Obama won blue districts.

  10. How would you determine the frequency of Obama supporters in Seattle? Obama WA 61.2% Region 60.6% U.S. 52.9% ? Popular vote in 2012 by Congressional district. Romney won red districts, Obama won blue districts.

  11. How would you determine the frequency of Obama supporters in Seattle? Obama WA 61.2% Region 60.6% U.S. 52.9% Utah? 24.7% ? ? Popular vote in 2012 by Congressional district. Romney won red districts, Obama won blue districts.

  12. Benefits of analyses of anonymized records • Quality assurance/quality control • Evaluation of population genetic assumptions used for statistical weights • Are populations uniform at city/state/region/nation levels? • Are similar close relatives common? • Use of real-world data in place of simulations

  13. Benefits of analyses of anonymized records • Quality assurance/quality control • Evaluation of population genetic assumptions used for statistical weights • Use of real-world data in place of simulations • What fraction of 3-person mixtures look like 2-person mixtures? • How evenly distributed is DNA profile space?

  14. It is time for disclosure of the NDIS database • Open access to data is a fundamental tenet of science. • Anonymized records would be easily copied and pose little (if any) privacy risk. • Time for DNA disclosure • Science, 2009; 326:1631-1632.

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