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Treatment appropriate

HBeAg. Anti-HBe. Treatment appropriate. Treatment appropriate. HBV DNA. ALT. Immune tolerant. Immune active. Inactive carrier state. HBeAg-negative CHB. Normal or minimal hepatitis. Chronic hepatitis. Normal or inactive hepatitis. Progressive fibrosis. Cirrhosis HCC.

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Treatment appropriate

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  1. HBeAg Anti-HBe Treatment appropriate Treatment appropriate HBV DNA ALT Immunetolerant Immuneactive Inactivecarrier state HBeAg-negative CHB Normal or minimal hepatitis Chronic hepatitis Normal orinactive hepatitis Progressive fibrosis Cirrhosis HCC CHB is a dynamic disease and patients can transition backwards and forwards between stages

  2. *HBV DNA levels often fluctuate; †May reactivate Based on a conversion factor of 1 IU/mL = 5.26 copies/mL

  3. Includes • individuals from all geographic regions exceptsmall towns of North America, Northern Europe • household and sexual contacts of HBV carriers • injection drug users • individuals having sex with multiple partners • individuals infected with a sexually transmitted disease, including HIV • inmates of correctional facilities • individuals with chronic liver disease • healthcare and public safety workers • patients undergoing renal dialysis • all pregnant women • Important to consider and discuss with the patient, the potential impact of possible results before commencing screening

  4. Initial screening tests • HBsAg: Indicates current infection • anti-HBs: Indicates immunity (vaccination or past infection) • IgG anti-HBc: Indicates infection, either past or ongoing • If HBsAg positive, undertake the following investigations to better characterize stage of HBV infection • HBeAg • anti-Hbe • HBV DNA • ALT / AST • complete blood count

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