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Why Study Skeletal Problems. Skeletal disease reduce the mass and quality of bone They cause millions of fractures/year and costs tens of billions of dollars in therapy and rehabilitation
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Why Study Skeletal Problems • Skeletal disease reduce the mass and quality of bone • They cause millions of fractures/year and costs tens of billions of dollars in therapy and rehabilitation • A 25% mortality rate within a year in older subjects who experience a hip fracture due to secondary ailments • A 50-year old Caucasian female has a higher chance of dying due to a fracture than due to breast cancer! • Although many new therapies have been developed, they often have serious side effects • Require reliable, non-invasive diagnostic tools to determine the need for and duration of therapy
Figure 5: Dynamic analysis of bone samples at various stages of bone loss indicated by amount of BMD. Experiments