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Cutaneous Carcinosarcoma. Department of Medicine, Division of Hematology/ Oncology, Department of Pathology Department of Surgery, Division of Surgical Oncology Feinberg School of Medicine, Northwestern University, Chicago, IL.
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Cutaneous Carcinosarcoma Department of Medicine, Division of Hematology/ Oncology, Department of Pathology Department of Surgery, Division of Surgical Oncology Feinberg School of Medicine, Northwestern University, Chicago, IL Katy H. Goldsborough, William B. Laskin, Jeffrey D. Wayne, Mark Agulnik
Carcinosarcomas (CS): Background • Malignant neoplasm • Biphasic epithelial and mesenchymal elements • Breast, lung, urogenital, gastrointestinal • Hypothesis- Multiclonal vs. Monoclonal • IHC studies establish 2 distinct populations • Primary cutaneous CS • Dawson 1972 • Basal and squamous cell carcinoma • Pleomorphic/ atypical fibroxanthoma/ MFH
Case Report • 62 y.o. male • Subcutaneous 4 mm nodule lateral to sternum • Slow growth over 18 months • Excisional bx followed by wide local excision
Methods • All case reports and series of CCS • Search terms: • Carcinosarcoma • Carcinoma and sarcoma • Sarcomatous sarcoma • Biphasic sarcomatoid carcinoma • Spindle cell carcinoma • 48 publications reviewed
Results • Between 1972 and 2007: 74 cases of CCS have been reported.
Conclusions • Primary CCS is a rare disease. • 6th-8th decade of life • Survival predicted by: • Epithelial component • Growth pattern • Tumor size • Duration • LN involvement • Age
Conclusions • Treatment approach • Wide local excision • Negative margins • No defined role for adjuvant radiation therapy or chemotherapy.