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Cutaneous Carcinosarcoma

Cutaneous Carcinosarcoma. Department of Medicine, Division of Hematology/ Oncology, Department of Pathology Department of Surgery, Division of Surgical Oncology Feinberg School of Medicine, Northwestern University, Chicago, IL.

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Cutaneous Carcinosarcoma

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  1. Cutaneous Carcinosarcoma Department of Medicine, Division of Hematology/ Oncology, Department of Pathology Department of Surgery, Division of Surgical Oncology Feinberg School of Medicine, Northwestern University, Chicago, IL Katy H. Goldsborough, William B. Laskin, Jeffrey D. Wayne, Mark Agulnik

  2. Carcinosarcomas (CS): Background • Malignant neoplasm • Biphasic epithelial and mesenchymal elements • Breast, lung, urogenital, gastrointestinal • Hypothesis- Multiclonal vs. Monoclonal • IHC studies establish 2 distinct populations • Primary cutaneous CS • Dawson 1972 • Basal and squamous cell carcinoma • Pleomorphic/ atypical fibroxanthoma/ MFH

  3. Case Report • 62 y.o. male • Subcutaneous 4 mm nodule lateral to sternum • Slow growth over 18 months • Excisional bx followed by wide local excision

  4. Methods • All case reports and series of CCS • Search terms: • Carcinosarcoma • Carcinoma and sarcoma • Sarcomatous sarcoma • Biphasic sarcomatoid carcinoma • Spindle cell carcinoma • 48 publications reviewed

  5. Results • Between 1972 and 2007: 74 cases of CCS have been reported.

  6. Results

  7. Conclusions • Primary CCS is a rare disease. • 6th-8th decade of life • Survival predicted by: • Epithelial component • Growth pattern • Tumor size • Duration • LN involvement • Age

  8. Conclusions • Treatment approach • Wide local excision • Negative margins • No defined role for adjuvant radiation therapy or chemotherapy.

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