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Cutaneous Malignant Melanoma

Cutaneous Malignant Melanoma. M. F. Fears TR, Tucker MA. J Natl Cancer Inst . 2005, 97:1789-90. Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov ). Frances Noonan, EOH,SPHHS drmfpn@gwumc.edu 202-994-3970. Photobiology of melanoma.

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Cutaneous Malignant Melanoma

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  1. Cutaneous Malignant Melanoma M F Fears TR, Tucker MA. J Natl Cancer Inst. 2005, 97:1789-90 Surveillance, Epidemiology, and End Results (SEER) Program (www.seer.cancer.gov) Frances Noonan, EOH,SPHHS drmfpn@gwumc.edu 202-994-3970

  2. Photobiology of melanoma • Wavelengths responsible-UVA, UVB or both ? • Critical UV-induced molecular alterations to melanocytes ? • Pigment- protective or promotional ? • Role of the immune system – UV effects on immunity? Frances Noonan, EOH,SPHHS

  3. Melanoma induced by UV irradiation of HGF/SF transgenic mice Noonan et al., Nature, 2001; Recio et al, Cancer Res, 2002; in prep Frances Noonan, EOH,SPHHS

  4. Functional Mc1r is necessary for UV-induced melanoma YELLOW BLACK BLACK Frances Noonan, EOH,SPHHS

  5. Neonatal host UV irradiation promotes melanoma outgrowth Frances Noonan, EOH,SPHHS Heather Poetschke-Klug et al

  6. Acknowledgements • Photobiology lab, GWUMC • Ed De Fabo • J. Bahn; research assistants and students • Agnieszka Wolnicka-Glubisz; Stephanie Constant; Jesse Damsker • Glenn Merlino, NCI/NIH • Miriam Anver, SAIC, FCRF • Funding- NCI/NIH; Elaine Snyder Cancer Research Fund, GWUMC Frances Noonan, EOH,SPHHS

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