160 likes | 294 Views
The Role of Insulin-Like Growth Factor-1 in Schizophrenia. By Karen Kiernan. Schizophrenia - Impaired Glucose Tolerance - Insulin Resistance - Type 2 Diabetes Mellitus Antipsychotics?. Aim of Article. Aim of Article. Role of IGF-1 deficiency
E N D
The Role of Insulin-Like Growth Factor-1 in Schizophrenia By Karen Kiernan
Schizophrenia - Impaired Glucose Tolerance - Insulin Resistance - Type 2 Diabetes Mellitus Antipsychotics? Aim of Article
Aim of Article Role of IGF-1 deficiency - Insulin Resistance - Pathogenesis of Schizophrenia
IGF-1 • Protein Hormone • Similar structure to Insulin • Stimulates cell growth • Inhibits apoptosis
Experiment • Patients with Schizophrenia - no previous treatment with psychotropic medication • Healthy Comparison Subjects • Low risk of Diabetes
Simplified Indian Diabetes Risk Score Age [years] < 35 0 35 - 49 20 ≥ 50 30 Abdominal obesity Waist <80 cm [female] , <90 [male] 0 Waist ≥ 80 – 89 cm [female], ≥ 90 – 99 cm [male] 10 Waist ≥90 cm [female], ≥ 100 cm [male] 20 Physical activity Exercise [regular] + strenuous work 0 Exercise [regular] or strenuous work 20 No exercise and sedentary work 30 Family history No family history 0 Either parent 10 Both parents 20 Minimum score 0 Maximum score 100
Method 12 hour overnight fast - Glucose - Insulin - IGF-1
Results Schizophrenia Patients - Glucose – Similar to healthy subjects High Insulin Low IGF-1 High Insulin Resistance Negative correlation between Insulin and IGF-1
Connection with Schizophrenia? • Deficiency of IGF-1 - Increased incidence of DM among patients with Schizophrenia - Pathogenesis of Schizophrenia itself?
IGF-1 deficiency Low Birth Weight Leanness Decrease in stature All indicate increase risk of Schizophrenia Also - Negative Cancer correlation
Genetics Chromosome 12p13-q13 - Linked with Schizophrenia - Close to gene coding for IGF-1
Pathogenesis IGF-1 Neuro-protective Anti-apoptotic effect Crucial for optimal neurodevelopment
Specific Hypothesis High concentrations of IGF-1 receptors in Hippocampus Hippocampus dysfunction in Schizophrenia - Auditory Hallucinations Higher deficiency of IGF-1 - More severe Auditory Hallucinations
Conclusion • Strong evidence of link • More studies needed!
Source • Insulin and Insulin like growth factor1 anormalities in antipsychotic naive schizophrenia • American Journal on Psychiatry, October 2007