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Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation

Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation. Osteoscoop - Issue N°234 – April 2012. Osteoclast progenitor. Preosteoclast. IGFBP-2. Osteoclasts. IGF-I. Bone resorption. Osteoclast progenitor. Preosteoclast. IGFBP-2. Osteoclasts. IGF-I.

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Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation

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  1. Insulin-like growth factor-binding protein-2 is required for osteoclast differentiation Osteoscoop - Issue N°234 – April 2012

  2. Osteoclast progenitor Preosteoclast IGFBP-2 Osteoclasts IGF-I Bone resorption

  3. Osteoclast progenitor Preosteoclast IGFBP-2 Osteoclasts IGF-I Osteoclast progenitor Bone resorption IGF-I - HBD IGF PTEN-P PTEN PTEN

  4. Osteoclast progenitor Preosteoclast IGFBP-2 Osteoclasts AKT-P AKT IGF-I Osteoclast progenitor Bone resorption IGF-I - - PI3K HBD IGF PTEN-P PTEN PTEN

  5. Osteoclast progenitor Preosteoclast IGFBP-2 Osteoclasts Cellsurvival AKT-P AKT-P AKT IGF-I IGF-I Osteoclast progenitor Bone resorption PI3K PTEN-P PTEN - - HBD IGF PTEN

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