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Suppl. Figure 1

Suppl. Figure 1. 1: Hematological system development and Function. 2: Cellular movement. 3: Immune cell trafficking. 4: Cell-to-cell signaling and interaction. 5: Inflammatory response. 6: Small molecular chemistry. 7: Lipid metabolism. 8: Molecular transport. 9: Tissue development.

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Suppl. Figure 1

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  1. Suppl. Figure 1 1: Hematological system development and Function. 2: Cellular movement. 3: Immune cell trafficking. 4: Cell-to-cell signaling and interaction. 5: Inflammatory response. 6: Small molecular chemistry. 7: Lipid metabolism. 8: Molecular transport. 9: Tissue development

  2. Suppl. Figure 2 -log(p-value) -log(p-value) -log(p-value) A B 0.0 0.0 0.0 1.0 1.0 1.0 2.0 2.0 2.0 3.0 3.0 3.0 C Intrinsic Prothrombin Activation Pathway Intrinsic Prothrombin Activation Pathway Intrinsic Prothrombin Activation Pathway Coagulation System Coagulation System Coagulation System Extrinsic Prothrombin Activation Pathway HIF1α Signaling HIF1α Signaling Type II Diabetes Mellitus Signaling Type II Diabetes Mellitus Signaling p38 MAPK Signaling Type II Diabetes Mellitus Signaling p70S6K Signaling p70S6K Signaling Extrinsic Prothrombin Activation Pathway HIF1α Signaling Extrinsic Prothrombin Activation Pathway HMGB1 Signaling p38 MAPK Signaling Threshold Threshold Threshold p38 MAPK Signaling

  3. Suppl. Figure 3 A B C Role of Pattern Recognition Receptors in Recognition of Bacteria and Virus Role of Pattern Recognition Receptors in Recognition of Bacteria and Virus Clathrin-mediated Endocytosis Signaling -log(p-value) -log(p-value) -log(p-value) 0.0 0.0 0.0 2.0 2.0 1.0 4.0 4.0 2.0 6.0 6.0 3.0 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages TREM1 Signaling TREM1 Signaling MSP-RON Signaling Pathway MSP-RON Signaling Pathway TREM1 Signaling Crosstalk between Dendritic Cells and Natural Killer Cells Crosstalk between Dendritic Cells and Nature Killer Cells Crosstalk between Dendritic Cells and Natural Killer Cells Communication between Innate and Adaptive Immune Cells Communication between Innate and Adaptive Immune Cells IL-12 Signaling and Production in Macrophages Role of cytokines in Mediating Communication between Immune Cells IL-12 Signaling and Production in Macrophages Dendritic Cell Maturation Caveolar-mediated Endocytosis Signaling Role of cytokines in Mediating Communication between Immune Cells IL-12 Signaling and Production in Macrophages Communication between Innate and Adaptive Immune Cells Role of cytokines in Mediating Communication between Immune Cells T Helper Cell Differentiation Threshold MSP-RON Signaling Pathway Threshold Threshold MIF-mediated Glucocorticoid Regulation T Helper Cell Differentiation Production of Nitric Oxide and Reactive Oxygen Species in Macrophages IL-10 signaling IL-10 signaling P38 MAPK Signaling MIF Regulation of Innate Immunity IL-6 signaling Role of Pattern Recognition Receptors in Recognition of Bacteria and Virus Airway Inflammation in Asthma IL-10 signaling IL-6 signaling Toll-like Signaling IL-6 signaling

  4. Suppl. Figure 4 A B C -log(p-value) -log(p-value) -log(p-value) 0.0 0.0 0.0 2.0 2.0 2.0 4.0 4.0 4.0 6.0 6.0 6.0 Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL 17-F Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL 17-F Acute Phase Response Signaling Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL 17-F TREM1 Signaling TREM1 Signaling Regulation of Cytokine Production in Intestinal Epithelial Cell by IL-17A and IL 17-F Regulation of Cytokine Production in Intestinal Epithelial Cell by IL-17A and IL 17-F TREM1 Signaling Regulation of Cytokine Production in Intestinal Epithelial Cell by IL-17A and IL 17-F Acute Phase Response Signaling Acute Phase Response Signaling IL-12 Signaling and Production in Macrophages IL-12 Signaling and Production in Macrophages Dendritic Cell Maturation IL-12 Signaling and Production in Macrophages IL—17A in Arthritis Chemokine Signaling Role of cytokines in Mediating Communication between Immune Cells Role of cytokines in Mediating Communication between Immune Cells Role of cytokines in Mediating Communication between Immune Cells T Helper Cell Differentiation IL-10 signaling T Helper Cell Differentiation Airway Pathology in Chronic Obstructive Pulmonary Disease P38 MAPK Signaling Airway Pathology in Chronic Obstructive Pulmonary Disease IL-17A Signaling in Gastric Cells IL-10 signaling IL-10 signaling IL-6 signaling IL-6 signaling IL-6 signaling Role of IL-17F in Allergic Inflammatory Airway Disease Role of IL-17F in Allergic Inflammatory Airway Disease Role of IL-17F in Allergic Inflammatory Airway Disease Threshold Threshold Threshold

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