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Work Reports

Work Reports. Zhang Qi 2012-12-21. Introduction. Sythesis of pH-sensitive prodrug monomer. 1. Synthesis of MPEG-PLA-NPC. 2. Synthesis of MPEG-PLA-NHNH 2. 3. Synthesis of Curcumin acetyl propionylation. 实验一 . 姜黄素：乙酰丙酸 =1: 1.

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Work Reports

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  1. Work Reports Zhang Qi 2012-12-21

  2. Introduction

  3. Sythesis of pH-sensitive prodrug monomer

  4. 1. Synthesis of MPEG-PLA-NPC

  5. 2. Synthesis of MPEG-PLA-NHNH2

  6. 3. Synthesis of Curcumin acetyl propionylation

  7. 实验一. 姜黄素：乙酰丙酸=1: 1 处理方法：产物过滤除去沉淀，除去溶剂，加入乙酸乙酯和HCl萃取。 结果 ：水相颜色较深，杂质较多，为找到合适的处理方法。 有机相颜色较浅，点板分析有两个点，但极性相近，过柱分离。 洗脱剂条件优化：选用1,2-二氯乙烷洗脱，但洗脱速度慢。 产物滴入乙醚中未出现沉淀。

  8. 实验二. 姜黄素：乙酰丙酸=1: 10 实验三. 姜黄素：乙酰丙酰氯=1: 10 处理方法：产物过滤除去沉淀，除去溶剂，加入乙酸乙酯和HCl萃取。 结果 ：有机相颜色深，点板均出现两个极性相近的点，待过柱分离 而水相中产物较少

  9. 实验四. 姜黄素：乙酰丙酰氯=1: 1

  10. Problems • 萃取后水相中的产物橙红色，不溶于有机溶剂，有DMAP，HCl等水溶性杂质，无法纯化确定结构。 • 2. 有机相中产物点板均出现两个点，但与姜黄素的位置不同，过柱不能完全分开，且产物结构不能确定。

  11. Thank you！

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