1 / 5

Morquio A: Endurance

Morquio A: Endurance. Endurance testing assesses functional capacity. Endurance tests measure the efficiency of performing a task and provide assessments of: Functional status of the cardiac, respiratory and musculoskeletal systems Overall disease progression Quality of life

ita
Download Presentation

Morquio A: Endurance

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Morquio A: Endurance

  2. Endurance testing assesses functional capacity Endurance tests measure the efficiency of performing a task and provide assessments of: • Functional status of the cardiac, respiratory and musculoskeletal systems • Overall disease progression • Quality of life • Response to treatments McDonald et al, J PediatrRehabil Med, 2010; Hendriksz et al, J Inherit MetabDis, 2012

  3. Submaximal intensity tests are sensitive indicators of endurance for MPS patients Recommended endurance tests for assessing submaximal functional capacity in Morquio A patients include: 6 minute walk test (6MWT) • measures how far a person can walk on a hard, flat surface in 6 minutes • a standardized test (American Thoracic Society, 2002) • used to assess endurance in patients with MPS VI (Harmatz et al, 2005) and Morquio A (Harmatz et al, 2013) 3 minute stair climb (3MSCT) • measures how many steps a person can ascend in 3 minutes, using rails and resting as needed • used to assess endurance in patients with MPS VI (Harmatz et al, 2005) and Morquio A (Harmatz et al, 2013) Image courtesy of Elizabeth Wright Harmatz et al, Mol Genet Metab, 2013; Harmatz et al, Pediatrics, 2005; McDonald et al, J PediatrRehabil Med, 2010; Hendriksz et al, J Inherit MetabDis, 2012

  4. Endurance is impaired in Morquio A Mean 6MWT = 212.6 ±152.2 m (n = 316 subjects) Mean 3MSCT = 30.0 ±24.0 stairs (n= 274 subjects) Mean 6MWT Mean 3MSCT n=215 n=59 n=274 n=248 n=68 n=316 Harmatz et al, Mol Genet Metab, 2013 MorCAP baseline data

  5. Regular assessments are recommended for optimal patient quality of life Hendriksz et al, J Inherit MetabDis, 2012

More Related