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CKiD Study Design

CKiD Study Design. Observational Cohort Study - 5 year study (Oct 2003 – Jul 2008) 5 year renewal (Aug 2008 – Jul 2013) - Enrollment period: Apr 2005 – Mar 2008 560 Children - Mild to moderately impaired kidney function - Age between 1 and 16 years.

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CKiD Study Design

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  1. CKiD Study Design • Observational Cohort Study - 5 year study (Oct 2003 – Jul 2008) 5 year renewal (Aug 2008 – Jul 2013) - Enrollment period:Apr 2005 – Mar 2008 • 560 Children - Mild to moderately impaired kidney function - Age between 1 and 16 years DCC: Munoz, JHU BSPH, Baltmore; CCC’s: PI’s Furth, JHU, Baltimore & Warady, CMH, KansasCity; Central Lab: Schwartz, U Rochester

  2. CKiD Study Goals • Define risk factors for CKD progression • Define effects of CKD progression on: -Neurocognitive development/function - Prevalence of CVD risk factors - Growth failure May 09 3

  3. CKiD Measurements According to Time-on-Study Enrollment Measurements Year 1 Year 2 Year 3 Year 4 Year 5 Year 6   Kidney:, Renal Panel*, CBC*, proteinuria, albuminuria CV: Standardized BP* Growth: Height*, Weight*, Tanner Stage*, Waist & Hip Circumference*         GFR (Iohexol) (3 pt) Cystatin C (q visit)          Echo, ABPM, Carotid IMTa, Lipids PedsQOL, Cognitive, Behavior Tests, MRIa, High Risk Assessmentsa    wrCRP, iPTH, Vitamin D, FFQ DEXA Scana, Bone Agea    aSubcohort 4 CKiD *Locally performed tests

  4. CKiD Cohort N=560 a LBW: <2500g, US Rate=7.9% b VLBW: <1500g, US Rate=1.4% Data Source: SC Meeting 1/09

  5. Ancillary Studies- Process CKiD-I IRB (Local) Concept Sheet to DCC Approve/Disapprove within 4 weeks DCC SC Scientific Subcommittee

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