Esophageal Motility Disorders

1. Esophageal Motility Disorders

3. Functionally the esophagus can be considered in three zones (UES, body, LES). The upper esophageal sphincter (UES) is tonically closed and contracts during inspiration, preventing air from entering into the gastrointestinal tract, and reflux. It relaxes during swallow, belching and vomiting. The lower esophageal sphincter (LES) maintains a steady baseline tone (~20 mm Hg) to prevent gastric contents from entering the esophagus. The LES also contracts during periods of increased intra-abdominal pressure, preventing reflux due to the pressure build up in the abdomen. The esophagus has 2 muscle layers: the inner circular layer and the outer longitudinal layer. The longitudinal muscle shortens the esophagus, while the circular muscle forms lumen-occluding ring contractions. The combination of these localized contractions is responsible for peristalsis. The proximal esophagus contains striated muscle and the distal esophagus smooth muscle, with a long transition zone between. Striated muscle is �faster�.Functionally the esophagus can be considered in three zones (UES, body, LES). The upper esophageal sphincter (UES) is tonically closed and contracts during inspiration, preventing air from entering into the gastrointestinal tract, and reflux. It relaxes during swallow, belching and vomiting. The lower esophageal sphincter (LES) maintains a steady baseline tone (~20 mm Hg) to prevent gastric contents from entering the esophagus. The LES also contracts during periods of increased intra-abdominal pressure, preventing reflux due to the pressure build up in the abdomen. The esophagus has 2 muscle layers: the inner circular layer and the outer longitudinal layer. The longitudinal muscle shortens the esophagus, while the circular muscle forms lumen-occluding ring contractions. The combination of these localized contractions is responsible for peristalsis. The proximal esophagus contains striated muscle and the distal esophagus smooth muscle, with a long transition zone between. Striated muscle is �faster�.

4. Normal Phases of Swallowing Voluntary oropharyngeal phase � bolus is voluntarily moved into the pharynx Involuntary UES relaxation peristalsis (aboral movement) LES relaxation Between swallows UES prevents air entering the esophagus during inspiration and prevents esophagopharyngeal reflux LES prevents gastroesophageal reflux peristaltic and non-peristaltic contractions in response to stimuli capacity for retrograde movement (belch, vomiting) and decompression Primary peristalsis is a wave that strips the esophagus proximal to distal, pushing the food bolus aborally toward the stomach. In the body, the wave travels at 3-4 cm/s. Secondary peristalsis is induced by esophageal distension from retained bolus, reflux, or swallowed air. It�s role is to clear the esophagus of retained food. Tertiary contractions are simultaneous (nonperistaltic), dysfunctional contractions and have no known physiologic role and are seen more often in the elderly and can be induced by stimuli (stress, reflux, etc.).Primary peristalsis is a wave that strips the esophagus proximal to distal, pushing the food bolus aborally toward the stomach. In the body, the wave travels at 3-4 cm/s. Secondary peristalsis is induced by esophageal distension from retained bolus, reflux, or swallowed air. It�s role is to clear the esophagus of retained food. Tertiary contractions are simultaneous (nonperistaltic), dysfunctional contractions and have no known physiologic role and are seen more often in the elderly and can be induced by stimuli (stress, reflux, etc.).

5. Normal Swallowing Primary peristalsis is triggered by the swallowing center. Myogenic propagation occurs in the body of the esophagus.Primary peristalsis is triggered by the swallowing center. Myogenic propagation occurs in the body of the esophagus.

6. Motility Disorders upper esophageal UES disorders neuromuscular disorders esophageal body achalasia diffuse esophageal spasm nutcracker esophagus nonspecific esophageal dysmotility LES achalasia hypertensive LES primary disorders achalasia diffuse esophageal spasm nutcracker esophagus nonspecific esophageal dysmotility secondary disorders severe esophagitis scleroderma diabetes Parkinson�s stroke These can be further divided into hypomotlity and hypermotlity disorders.These can be further divided into hypomotlity and hypermotlity disorders.

7. Motility Disorders diagnostic tools cineradiology or videofluoroscopy (MBS) barium esophagram esophageal manometry endoscopy

8. Normal Manometry From S&F, 2002. Notice transition zone (mid-esophagus) with smaller amplitude contractions.From S&F, 2002. Notice transition zone (mid-esophagus) with smaller amplitude contractions.

9. Upper Esophageal Motility Disorders cause oropharyngeal dysphagia (transfer dysphagia) patients complain of difficulty swallowing tracheal aspiration may cause symptoms pharyngoesophageal neuromuscular disorders stroke Parkinson�s poliomyelitis ALS multiple sclerosis diabetes myasthenia gravis dermatomyositis and polymyositis upper esophageal sphincter (cricopharyngeal) dysfunction These disorders tend to be considered separately from disorders of the body and LES because they are usually due to problems with striated muscle or its extrinsic innervation.These disorders tend to be considered separately from disorders of the body and LES because they are usually due to problems with striated muscle or its extrinsic innervation.

10. UES Disorders cricopharyngeal hypertension elevated UES resting tone poorly understood (reflex due to acid reflux or distension) cricopharyngeal achalasia incomplete UES relaxation during swallow may be related to Zenker�s diverticula in some patients clinical manifestations localizes as upper (cervical) dysphagia within seconds of swallowing coughing, choking, immediate regurgitation, ornasal regurgitation diagnosis: swallow evaluation & modified barium swallow

11. Motility Disorders of the Body & LES symptoms: usually dysphagia (intermittent and occurring with liquids & solids) diagnostic tests barium esophagram endoscopy esophageal manometry disorders achalasia diffuse esophageal spasm (DES) nutcracker esophagus hypertensive LES nonspecific esophageal dysmotility hypomotility hypermotlity

12. Achalasia first clinically recognized esophageal motility disorder described in 1672, treated with whale bone bougie term coined in 1929 dual disorder LES fails to appropriately relax resistance to flow into stomach not spasm of LES but an increased basal LES pressure often seen (55-90%) loss of peristalsis in distal 2/3 esophagus Achalasia means �failure to relax.� Incomplete LES relaxation without aperistalsis can be an early manifestation of achalasia, but infrequently.Achalasia means �failure to relax.� Incomplete LES relaxation without aperistalsis can be an early manifestation of achalasia, but infrequently.

13. Achalasia epidemiology 1-2 per 200,000 population usually presents between ages 25 to 60 male=female Caucasians > others average symptom duration at diagnosis: 2-5 years pathology loss of ganglionic cells in the myenteric plexus (distal to proximal) vagal fiber degeneration underlying cause: unknown autoimmune? (antibodies to myenteric neurons in 50% of patients)

14. Achalasia clinical presentation solid dysphagia 90-100% (75% also with dysphagia to liquids) post-prandial regurgitation 60-90% chest pain 33-50% pyrosis 25-45% weight loss nocturnal cough and recurrent aspiration diagnosis plain film (air-fluid level, wide mediastinum, absent gastric bubble, pulmonary infiltrates) barium esophagram (dilated esophagus with taper at LES) good screening test (95% accurate) endoscopy (rule out GE junction tumors, esp. age>60) esophageal manometry (absent peristalsis, ? LES relaxation, & resting LES >45 mmHg)

15. Achalasia treatment - reduce LES pressure and increase emptying nitrates and calcium channel blockers 50-70% initial response; <50% at 1 year limitations: tachyphylaxis and side-effects botulinum toxin (prevents ACH release at NM junction) 90% initial response; 60% at 1 year pneumatic dilation (disrupt circular muscle) 60-95% initial success; 60% at 5 years recent series suggest 20-40% will require re-dilation risk of perforation 1-13% (usually 3-5%); death 0.2-0.4% surgical myotomy (open or minimally-invasive) >90% initial response; 85% at 10 years; 70% at 20 years (85% at 5 years with min. inv. techniques) <1% mortality; <10% major morbidity 10-25% acutely develop reflux, up to 52% develop late reflux Medical therapy usually reserved for individuals unwilling or unable to have more definitive therapy.Medical therapy usually reserved for individuals unwilling or unable to have more definitive therapy.

16. Spastic Motility Disorders of the Esophagus �lumper� approach normal achalasia spastic motility disorder �splitter� approach (radiology and manometry) diffuse esophageal spasm nutcracker esophagus hypertensive LES nonspecific esophageal dysmotility �splitting� has not resulted in a clinical benefit In studies, all 4 have similar presenting sxs, the pathogenesis of all 4 remains unknown (maybe the same), treatment approaches are similar for all 4, and outcomes do not vary with subtype. In all of these, its hard to show that sx improvement correlates to manometric improvement. In fact, you can find asx and symptomatic patients with the exact same motility patterns. Unlike achalasia, these conditions do not progress. Neither the history nor manometric findings are accurate enough to confirm an esophageal cause for chest pain.In studies, all 4 have similar presenting sxs, the pathogenesis of all 4 remains unknown (maybe the same), treatment approaches are similar for all 4, and outcomes do not vary with subtype. In all of these, its hard to show that sx improvement correlates to manometric improvement. In fact, you can find asx and symptomatic patients with the exact same motility patterns. Unlike achalasia, these conditions do not progress. Neither the history nor manometric findings are accurate enough to confirm an esophageal cause for chest pain.

17. Diffuse Esophageal Spasm frequent non-peristaltic contractions simultaneous onset (or too rapid propagation) of contractions in two or more recording leads occur with >30% of wet swallows (up to 10% may be seen in �normals�) This condition is often split from the rest because the response to swallows is non-peristaltic. This condition is often split from the rest because the response to swallows is non-peristaltic.

19. Nonspecific Esophageal Dysmotility high LES pressure >45 mm Hg normal peristalsis often overlaps with other motility disorders abnormal motility pattern fits in no other category non-peristalsis in 20-30% of wet swallows low pressure waves (<30 mm Hg) prolonged contractions 1/3 of pts with non-specific dysmotility will have LES hypertension.1/3 of pts with non-specific dysmotility will have LES hypertension.

20. Spastic Motility Disorders of the Esophagus epidemiology any age (mean age 40) female > male symptoms dysphagia to solids and liquids intermittent and non-progressive present in 30-60%, more prevalent in DES (in most studies) chest pain constant % across the different disorders (80-90%) swallowing is not necessarily impaired can mimic cardiac chest pain pyrosis (20%) and IBS symptoms (>50%) symptoms and manometry correlate poorly Pts often present with both sxs. Rare to see weight loss due to dysphagia here.Pts often present with both sxs. Rare to see weight loss due to dysphagia here.

21. Some anecdotal evidence that the drugs can improve manometric findings, but clinical trials have been disappointing. In the trazodone (100-150 mg/d) study, a significant improvement was seen but it was not dependent on manometric improvement. A JAMA trial of dilation found a positive effect equaled by a placebo dilator.Some anecdotal evidence that the drugs can improve manometric findings, but clinical trials have been disappointing. In the trazodone (100-150 mg/d) study, a significant improvement was seen but it was not dependent on manometric improvement. A JAMA trial of dilation found a positive effect equaled by a placebo dilator.

22. Manometry in Esophageal Symptoms

23. Hypomotilty Disorders primary (idiopathic) aging produces gradual decrease in contraction strength reflux patients have varying degrees of hypomotility more common in patients with atypical reflux symptoms usually persists after reflux therapy defined as low contraction wave pressures (<30 mm Hg) incomplete peristalsis in 30% or > of wet swallows

24. Hypomotilty Disorders secondary scleroderma in >75% of patients progressive, resulting in aperistalsis in smooth-muscle region incompetent LES with reflux other �connective tissue diseases� CREST polymyositis & dermatomyositis diabetes 60% with neuropathy have abnormal motility on testing (most asx) other hypothyroidism, alcoholism, amyloidosis

25. Nonischemic Chest Pain remains poorly understood (functional chest pain) enthusiastic investigation finds numerous associations in studies psychiatric disorders (depression, panic or anxiety disorder�) esophageal disorders (GERD, motility disorders�) musculoskeletal disorders cardiac disease (microvascular, MVP, tachyarrhythmias�) GERD is by far the most common, diagnosable, esophageal cause 50-60% of patients have heartburn or acid regurgitation symptoms 50% have abnormal esophageal pH studies (not always correlating to sxs) very low incidence of endoscopic findings �PPI Test� may be best and most cost-effective approach a small subset of patients with non-GERD NCCP display a variety of esophageal motility disorders symptoms and motility findings correlate poorly esophageal hypersensitivity/hyperalgesia may explain the symptoms