1 / 20

Kuliah Pakar TUBERKULOSIS

Kuliah Pakar TUBERKULOSIS. Febtarini . R, dr. Sp.PK IKT- FKUWKS Sabtu , 12- April- 2014. Tuberkulosis ( Global Health Emergency ). 1/3 pdd dunia terinfeksi kuman TB 5-10% TB non HIV 11-13% HIV + TB 80% TB+ HIV Afrika. Kematian utama HIV krn TB. Usia produktif 20 – 49 tahun. MDR

jake
Download Presentation

Kuliah Pakar TUBERKULOSIS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. KuliahPakarTUBERKULOSIS Febtarini. R, dr. Sp.PK IKT- FKUWKS Sabtu, 12- April- 2014

  2. Tuberkulosis(Global Health Emergency) 1/3 pddduniaterinfeksikuman TB 5-10% TB non HIV 11-13% HIV + TB 80% TB+ HIV Afrika Kematianutama HIV krn TB Usiaproduktif 20 – 49 tahun MDR Asia tenggara 35% Afrika 30% Pasifikbarat 20% Vaksin BCG BaccilleCalmette-Guerin Indonesia, TB tertinggikelimadidunia PenyebabkematiantertingginomertigadiInd 1

  3. Peran Lab : deteksicepat/ dini identifikasiMycobacterium 2

  4. MTBMycobacterium tuberculosis 3

  5. Penularan Inhalasi Droplet infection Lingkunganpadatpenduduk Pemukimanperkotaan Lembab Gelap Kurangkebersihan MTBSal.npsmakrofagalveolarmaturasifagosom- (survive, berkembangbiak dlmmakrofag) produksifaktor ESAT 6/ Early secreted antigenic target InaktivasiLimfosit T, respons – (pengenalan & eliminasiintraseluler -) 4

  6. Responsimunygbisaterjadi : 5

  7. Infeksi primer/ Ghon ke jar. Tbh lain mellsistemik vena  pleura = efusi GIT, Limfe, orofaring, kulit otak, ginjal, tulang  Arteripulmonalisseluruhbagianparu TB Milier 6

  8. 7

  9. TBC primerbakteridormantinfeksi endogen TB sekunder/ post primer Dx TB : • GxKlinis = respiratorik, sistemik, TB ekstraparu • Pemeriksaanfisik • Pemeriksaanbakteriologi bahan : sputum,cairanpleura,likuor,BAL,darah skriningserologikonfirmasi • Ro : Foto thorax PA berawansegmenapikal,posteriorlobusatas,superiorlobusbwh kavitas, efusi pleura, bercakmilier 8

  10. 9

  11. 10

  12. PemeriksaanLaboratorium • Sputum = a. BTA mikroskopik b. Kultur, media Lowenstein Jensen • Kulturalatotomatis & teskepekaanantibiotika • PCR/ Polymerase chain reaction techniques • Antigen TB test • Antibodi TB rapid test (screening test) 11

  13. Pemeriksaan sputum 12

  14. Skalakuantitasirekomendasi WHO & IUATLD (International Union Against Tuberculosis and Lung Disease) 13

  15. 14

  16. Kulturotomatis Deteksikumandanteskepekaan / resistensiantibiotika (4-21hr) Media kultur, misalnya : - Micobacteria Growth Indicator Tube (MGIT) - Bact/Alert - ESP Mice - MB Redox - KRD Niche B - Biphasic Septic-Check AFB & Mice-Acid - Bactec MGIT960 15

  17. Polymerase Chain Reaction (PCR) EkstraksiDNAamplifikasiregio DNA spesifik (thermal cycler)pembacaanmenggunakanelektroforesis gel ygdiwarnai dg Ethidium bromide) sensitivitas 71 – 98% spesifisitasmendekati 100% Deteksi antigen 3 – 3,5 jam 16

  18. Ag TB Rapid Test Deteksi Ag denganmenggunakan : ELISA Latex agglutination Reverse Passive Haemagglutination test 17

  19. Antibodi TB Rapid test Immunochromatographic assay/ Lateral-flow test/ Simply strip test (pengembanganmetodeagglutination test) Tesserologiuntukskrining/ penyaring, deteksidini Keuntungan : • Penderitaygtidakbanyakproduksi sputum • Bilamikroskopiknegatif (sulitmendapatkan BTA) • TB ekstraparu • Waktusingkat, mudahdigunakan, stabil,relatifekonomis. 18

  20. THANKS,..

More Related