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Parametric Sensitivity Analysis

. Parametric Sensitivity Analysis. Parametric sensitivity analysis investigates the relationship between the variables and parameters in a biochemical network.. Variables1. Concentrations2. Pathway fluxes3. Dynamic response4. Growth rate5. ..... Parameters1. Enzyme activity levels2. Kinetics constants3. Decay rates4. Boundary conditions5. .....

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Parametric Sensitivity Analysis

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    3. Parametric Sensitivity Analysis: Example

    7. Sensitivity Analysis: General Computation

    8. Application: unregulated chain

    10. Application: product feedback

    12. Metabolic Control Analysis (MCA)

    13. Utility of MCA

    14. Utility of MCA

    15. Utility of MCA

    17. Time-Varying Sensitivities

    18. Example

    19. Application to Phototransduction Pathway

    20. Global Sensitivity Analysis Addresses system behaviour over a wide range of parameter values Primarily statistical tools: efficient sampling methods Provides a broader view of behaviour, but… Results often difficult to interpret

    21. Applications of Sensitivity Analysis Predicting the effect of interventions Drug development

    22. Applications of Sensitivity Analysis Predicting the effect of interventions Drug development Medicine

    23. Applications of Sensitivity Analysis Predicting the effect of interventions Drug development Medicine Metabolic engineering

    24. Applications of Sensitivity Analysis Predicting the effect of interventions Drug development Medicine Metabolic engineering Model construction and analysis Identifying key variables

    25. Applications of Sensitivity Analysis Predicting the effect of interventions Drug development Medicine Metabolic engineering Model construction and analysis Identifying key variables Model calibration

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