1 / 41

MACROCYTIC ANEMIAS

MACROCYTIC ANEMIAS. These are the anemias in which the RBC have an MCV of greater than 100flThere are 2 groups of macrocytic anemiasMegaloblastic anemiaNon megaloblastic macrocytic anemia. Requirements for Red Blood Cell Production . ErythropoeitinProteins, required for globin synthesisIron Vi

jebediah
Download Presentation

MACROCYTIC ANEMIAS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. MACROCYTIC ANEMIAS

    2. MACROCYTIC ANEMIAS These are the anemias in which the RBC have an MCV of greater than 100fl There are 2 groups of macrocytic anemias Megaloblastic anemia Non megaloblastic macrocytic anemia

    3. Requirements for Red Blood Cell Production Erythropoeitin Proteins, required for globin synthesis Iron Vitamin B12 and folic acid Vitamin B6 Vitamin C Thyroid hormones, estrogens and androgens

    4. MEGALOBLASTIC ANEMIA These are a group of disorders in which the cause the anemia is due to deficiency of vitamin B12 and folic acid The macrocytes in this condition is usually oval - hence they are also called as MACRO OVALOCYTES

    5. NON MEGALOBLASTIC MACROCYTIC ANEMIAS These are disorders in which the macrocytosis is not due to vitamin B12 or folic acid deficiency Here the macrocytes are ROUND The conditions in which such round macrocytes are seen are Reticulocytosis Hypothyroidism / myxedema Myelodysplastic syndrome Scurvy (Vit-C dif) Sideroblastic anemia Liver disorders

    6. MEGALOBLASTIC ANEMIA Vitamin B12 and folic acid are important nutrients required in the process of nuclear maturation They are required during erythropoiesis (during DNA synthesis) These anemias may be caused because of a nutritional deficiency or impaired absorption mainly.

    7. MEGALOBLASTIC ANEMIA Impaired DNA synthesis leading to defective cell maturation and cell division Nuclear maturation delays from the cytoplasmic maturation NUCLEAR CYTOPLASMIC ASYNCHRONY Abnormally large erythroid precursors and red cells

    8. Affect all marrow elements. Neurologic symptoms (dorsal columns) Ineffective erythropoiesis: High indirect bilirubin Very high LDH

More Related