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An autonomous molecular computer for logical control of gene expression

An autonomous molecular computer for logical control of gene expression. Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar & Ehud Shapiro Weizmann Institute of Science, Israel.

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An autonomous molecular computer for logical control of gene expression

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  1. An autonomous molecular computer for logical control of gene expression Yaakov Benenson, Binyamin Gil, Uri Ben-Dor, Rivka Adar & Ehud Shapiro Weizmann Institute of Science, Israel

  2. An autonomous biomolecular computer that, logically analyzes the levels of mRNA species, and in response produces a molecule capable of affecting levels of gene expression, which is a drug. • Logical design and modular organization • Input - Identification of disease indicators • Computation - Diagnosis • Output – Drug administration

  3. Example diagnostic rules • Small-cell lung cancer • If ASCL1↑ & GRIA2↑ & INSM1↑ & PTTG↑ then Administer TCTCCCAGCGTGCGCCAT (oblimersen-a drug that may kill cancer cells by blocking the production of a protein that makes cancer cells live longer. Also called bcl-2 antisense oligodeoxynucleotide G3139 and augmerosen) • Prostate cancer • If PPAP2B↓ & GSTP1↓ & PIM1↑ & HPN↑ then Administer GTTGGTATTGCACAT(MDM2 antisense strand)

  4. Regulation of competing transitions

  5. Validation of the diagnostic automata

  6. Demonstration of Drug Administration

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