1 / 9

In silico feedback for in vivo regulation of a gene expression circuit

In silico feedback for in vivo regulation of a gene expression circuit. Shared by lxshen. Biological feedback. Signals Biological control circuits Implement of control. Comparison of control circuits. Synthetic biological circuits. Electronic circuits. Prosperous Easy to control

jenniferfranklin
Download Presentation

In silico feedback for in vivo regulation of a gene expression circuit

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. In silico feedback for in vivo regulation of a gene expression circuit Shared by lxshen

  2. Biological feedback • Signals • Biological control circuits • Implement of control

  3. Comparison of control circuits Synthetic biological circuits Electronic circuits Prosperous Easy to control More functions Fast • Nature circuits robust • Difficulty in artificial circuits • Not easy to control • slow

  4. Interface

  5. model • Fourth-order linear ordinary differential equation • Identification experiment to determine five parameters fluorescence delay (fluorescence ≠ gene expression)

  6. Applying model Ⅰ • Task: increasing fluorescence 4 or 7 times over a 7-h period • Open-loop(OL)control • Fail to regulate fluorescence to desired levels due to inaccuracies of the model and something unpredictable

  7. Applying model Ⅱ • Closed-loop(CL) feedback control • Kalman filter

  8. Significance • More predictable and accurate • Avoid the disadvantage of bio-circuits • Facilitate synthetic systems

  9. Q﹠A

More Related