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Adderall Analysis: A Comparison

Adderall Analysis: A Comparison. EJ Habina and Dan Palumbo. Purpose. Using FT-IR and NMR spectroscopy, evaluate an amphetamine salt isomer from a generic, prescription-brand adderall.

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Adderall Analysis: A Comparison

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  1. Adderall Analysis:A Comparison EJ Habina and Dan Palumbo

  2. Purpose • Using FT-IR and NMR spectroscopy, evaluate an amphetamine salt isomer from a generic, prescription-brand adderall. • Compare results and structure of the generic brand to a name brand adderall and see if any difference exists.

  3. Background • Adderall is a combination of amphetamine salts used as medication to treat ADHD and narcolepsy • Once Adderall enters the bloodstream, the amphetamines stimulate the brain's production of norepinephrine and dopamine

  4. Adderall Composition

  5. More Information • Detection and analysis of amphetamine salts is important in forensic science due to their widespread abuse • In non-ADHD users, Adderall produces a surge of focus and energy and an accompanying loss of appetite

  6. Method 1: FT-IR • Crush tablet of dextroamphetamine sulfate to a fine powder • Run an IR scan in Organic Lab • Determine structure based on peak reading • Follow procedure above for generic and name brand and compare peaks

  7. FT-IR Spectra – Generic

  8. FT-IR Spectra – Generic and Dextro salt

  9. FT-IR Spectra – All three samples

  10. Method 2: NMR • Dissolve 20mg of dextroamphetamine sulfate in 1mL D2O in an NMR tube • Run 13C-NMR 10k scans overnight • Collect spectra and determine peaks • Repeat for generic and name brand and compare results

  11. NMR Spectra – Dextro salt

  12. NMR Spectra – Generic

  13. NMR Spectra – Name Brand

  14. Results • We were able to produce successful spectra from both FT-IR and NMR for all three samples • Comparatively, we found the peaks were virtually identical for the name brand and generic brand on both instruments • We were also able to use the pure Dextro salt to identify specific peaks of interest as well as to prove our method was successful

  15. Discussion • Our original goal was to isolate one of the amphetamine salts and use it to spike a sample of pure Adderall • However, the isolation process requires dangerous chemicals and lengthy procedures • The one synthetic route we found is not stereo-selective so we could not tell which isomer we were isolating which set us up for error

  16. This is for Kiersten…

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