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Unit 2- Genetics. Meiosis. Sperm _____ chromosomes. Fertilization. Egg ____ chromosomes. X. Zygote 46 chromosomes. Which is diploid ? Which is haploid ?. 23 chromosomes. Sex cells. Egg 23 chromosomes. How can a diploid cell become haploid cells Answer: by the process of meiosis
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Unit 2- Genetics Meiosis
Sperm _____ chromosomes Fertilization Egg ____ chromosomes X Zygote 46 chromosomes Which is diploid ? Which is haploid ?
23 chromosomes Sex cells Egg 23 chromosomes How can a diploid cell become haploid cells Answer: by the process of meiosis Meiosis: process of cell division in which a diploid cell produces four haploid daughter cells; each with half the number of chromosomes found in the parent cell
Interphase • DNA replicates/duplicates (S phase) • In the form of chromatin • Not easily visible • Similar to interphase in Mitosis
Before any cell division, DNA must be duplicated • Were going to use a simpler cell in which 2n=4 • This cell have 4 unduplicated chromosomes right before meiosis occurs
Thus, this cell has 2 pairs of homologous chromosomes • We are now ready for meiosis with Playdoh
What you need • 3 different colored playdoh • One color for paternal chromosome • One color for maternal chromosome • One color for centromere • Paper or surface of whiteboard • Pen/marker to draw other details such as cell membrane, spindle fibers, centrioles etc. • Handout • Group of 3
2 parts of meiosis • Meiosis 1: reduction division • Meiosis 2: Gametes are produced • Unlike mitosis, meiosis does not occur in somatic cells of our body but rather in reproductive organs.
Prophase 1 Tetrad: the homologous pair made of 4 chromatids. • Chiasmata: region where crossing-over occurs.
Tetrad: the homologous pair made of 4 chromatids. • Chiasmata: region where crossing-over occurs.
Prophase 1 • Chromosomes condense and become visible; each with 2 identical sister chromatids. • Nuclear membrane dissolves; centrioles move to opposite cell poles; spindle fibers form • Homologous chromosomes pair up and form a tetrad • Crossing-over occuring between homologous chromosomes produce exchange genetic information
Metaphase 1 • Homologous chromosomes line up in PAIRS in the middle of the cell • Again: Homologous chromosomes do not line up in a single file; they line up in pairs in metaphase 1
Anaphase 1 • Homologous chromosomes (NOT individual sister chromatids) separate and move to opposite end of cell.
Telophase 1 • Two haploid cells (half of the original amount in each cell that is, 2 each) • Original cell (2n= 4 chromosomes) • Homologues reach opposite sides of the cell. • A nuclear membrane reforms forming 2 new nuclei • Chromosomes relax
Meiosis 2: similar to mitosisProphase 2 • Chromatin coil again • Spindle fibers attach to chromosomes • THERE IS NO DUPLICATION OF CHROMOSOME AT THIS STEP • No Crossing over either
Metaphase 2 • Chromosomes line up in single file RANDOMLY in the middle of each cell
Anaphase 2 • Centromeres split pulling sister chromatids to opposite end of each cell
Telophase 2 • Four nuclei form around chromosomes • Spindle fibers dissolve • Cells divide
Final result of meiosis Initial parent cell 2n=4 4 haploid daughter cells n = 2
Gametogenesis= the formation of gametes involves Spermatogenesis in male and oogenesis in female
Chromosome Crossing over • Only one chiasma is illustrated but many occur per pair (Plural: chiasmata)
Some new words • Gamete: a sex cell; includes sperm cells and egg cells • Zygote: a cell produced by the fusion of two gametes • Fertilization: the formation of a zygote by fusing two gametes • Haploid: a cell containing half the usual number of chromosomes (n) • Diploid: a cell containing two copies of each chromosome (2n)