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Pharmacosome Production

Leading the rapid development of novel vesicular drug delivery systems, Creative Biostructure builds up several advanced technology platforms for liposome production, including the pharmacosome technology, specifically for poorly soluble drug delivery. Based on the specialized knowledge and efficient pipelines, we can customize the production service according to your demands.<br>

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Pharmacosome Production

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  1. Pharmacosome Production —Creative Biostructure

  2. Leading the rapid development of novel vesicular drug delivery systems, Creative Biostructure builds up several advanced technology platforms for liposome production, including the pharmacosome technology, specifically for poorly soluble drug delivery. Based on the specialized knowledge and efficient pipelines, we can customize the production service according to your demands.

  3. How Pharmacosomes Work Instead of physically trapping drugs into vesicles, amphiphilic phospholipids in pharmacosomes are complexed with drugs via hydrogen bonds between active hydrogens and phospholipids. The drug molecule bearing an active hydrogen atom (-COOH, -OH, -NH2 etc.) can be converted to an ester with the hydroxyl moiety of the lipid, resulting in an amphiphilic complex that aids membrane, tissue, or cell wall transfer. The drug-lipid complex exists as a monomer at low concentrations, but a variety of structures (e.g. micelles, colloidal or hexagonal shape) might develop when the concentration increases. Eventually, the conjugated drug will be released from pharmacosomes upon chemical or enzymatic hydrolysis.

  4. Compared to other liposomal drug delivery systems, pharmacosomes have advantages such as minimized drug degradation and increased drug bioavailability. For example, limitations in transfersomes such as predisposition to oxidative degradation and impurity of natural phospholipids can be overcome by pharmacosomes.

  5. Pharmacosomes Applications • Pharmacosomes have been developed to enhance the solubility for both hydrophilic and lipophilic drugs, including non-steroidal anti-inflammatory drugs, proteins, cardiovascular and antineoplastic drugs. Pharmacosomes can be administered via oral, topically, or through extravascular and intravascular routes. • According to their amphiphilic nature, we can also design and synthesize suitable lipids to complex with desirable drugs. In addition, we have extensive experience in the selection of solvents and formulations for final products. We offer first-in-class services for pharmacosome preparation. 

  6. Meanwhile, in-house precise assays are available to evaluate their characteristics: • Complex Determination: Fourier-transform infrared spectroscopy (FTIR) • Surface Morphology: Scanning electron microscopy (SEM) or Transmission electron microscopy (TEM) • Solubility studies: shake –flask techniques • Determine the drug-excipients compatibility or interactions: Differential scanning calorimetry (DSC) • In vivo and in vitro drug release evaluations

  7. Contact Creative Biostructure • Mailing Address: 45-1 Ramsey Road Shirley, NY 11967, USA • Email Address: contact@creative-biostructure.com • Website: http://www.creative-biostructure.com

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