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Idiopathic pulm fibrosis (IPF) chronic interstitual lung dz -- honeycombed alveolar spaces alternating fibrosis and dilation Sx: resp difficulty, hypoxemia, cyanosis, cor pulmonale . IPF -- diffuse interstitual fibrosis What is the FEV1/FVC ratio? Normal b/c both are reduced.
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Idiopathic pulm fibrosis (IPF) chronic interstitual lung dz -- honeycombed alveolar spaces alternating fibrosis and dilation Sx: resp difficulty, hypoxemia, cyanosis, cor pulmonale
IPF -- diffuse interstitual fibrosis What is the FEV1/FVC ratio? Normal b/c both are reduced
IPF -- persistent injury leads to fibroblast proliferation and fibrosis Which cells participate? Lymphs, macros, type II pneumocytes
IPF on CXR radiodense linear streaking in lower lung fields
Sarcoidosis bilateral hilar lymphadenopathy (potato nodes) systemic dz of non-caseating granulomas Immune involvement: cell-mediated rxn to unknown antigen -- anergy to common skin test antigens
Asteroid bodies -- inclusions in giant cells -- also found in other granulomatous dzs
Schaumann bodies composed of calcium and protein. These are found in other granulomatous dz, also.
Intraaveolar hemorrhage -- hemosiderin macros What syndromes are associated with this? Goodpasture’s, Idiopathic Pulm Hemosiderosis, Vasculitis-Associated Hemorrhage
Silicosis thickened pleura upper lobe, white is collagen
Silicosis concentric collagen bands in nodules
Asbestos -- diffuse interstitual fibrosis Clinical course progressive dyspnea, cough, sputum, CHF, cor pulmonale
Asbestos -- pink homogenous fibrosis with thickened blood vessels
prominent interstitial markings in bases, pleural thickening at the costophrenic angles and lower lateral chest walls, and a calcified pleural plaque in the left hemidiaphragm
large right pleural effusion and more extensive pleural thickening -- mesothelioma on resection
Pulmonary infarct -- hemorrhagic, uncommon due to dual blood supply -- the more peripheral the embolus, the greater the chance for infarction
Pulmonary hypertension -- vessel hypertrophied and septa thickened