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INFLAMMATION

The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation. Department of Pathophysiology. INFLAMMATION. Lecture presentation. Professor Tezikov E.B.

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INFLAMMATION

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  1. The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation Department of Pathophysiology INFLAMMATION Lecture presentation Professor Tezikov E.B.

  2. Leukocytes migration and secretion of inflammatory mediators depending on the course of inflammation Onset Resolution

  3. Mechanisms formation of exudate and transudate Normal Fluid with low proteincontent Transudate Fluid with rich protein content Exudate

  4. Mechanisms increased vascular permeability in acute inflammation Endothelial cell contraction and cytoskeletal reorganization Direct endothelial damage Damage of endothelial cells by leukocytes Increased rate of transcytosis Increased permeability of vessels in angiogenesis

  5. Extravasation, chemotaxis and phagocytosis of neutrophils in acute inflammationи Chemokine activation of integrens Rolling Extravasation Endothelial cells Chemokines Cytokines Bacteria Macrophage

  6. Mechanisms of leukocyte migration Integrine activation Migration through endothelium Firm adhesion Rolling Low affinity integrene High affinity integrene PECAM-1 P-celectine Е-celectine ICAM-1 VCAM-1 Proteoglycan Chemokines TNF, IL-1 Macrophage

  7. Mechanism of chemotaxis Bacteria or dying cell Stromal cell Endothelium Neutrophil

  8. How leukocytes determine direction of movement? IL-8 LPS

  9. Stages of phagocytosis Recognition and attachment Engulfment of plasma membrane Formation of phagolysosome Killing and degradation

  10. Killing of bacteria during engalfmant

  11. Outcomes of acute inflammation

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