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Lecture 14/15 – Inflamation & Stress Signaling

Lecture 14/15 – Inflamation & Stress Signaling. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. Module 11: Inflamatory responses. Inflammatory responses The innate immune system is our first line of defense against invading pathogens.

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Lecture 14/15 – Inflamation & Stress Signaling

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  1. Lecture 14/15 – Inflamation & Stress Signaling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. Module 11: Inflamatory responses • Inflammatory responses • The innate immune system is our first line of defense against invading pathogens. • Initiates a vigorous and rapid inflammatory response to attack foreign pathogens • Plays a key role in activating the more slowly developing adaptive immune response. • Activation of specific B and T cells to extend the host defense system • Innate response is carried out by a complex series of cellular interactions, collectively known as the inflammatory response. • Cellular players in the innate immune response/inflamatory response are: • Blood platelets • Macrophages • Mast cells • Neutrophils • Endothelial cells Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  3. Module 11: Inflamation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  4. Module 11: Platelet Structure & Thrombus formation (A) (B) Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  5. Module 11 Figure platelet activation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  6. Module 11: Endothelial Cell Permeability Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  7. Module 11: Cell Proliferation • Platlet-derived growth factor – PDGF • Transforming growth factor b(TGF-b) • Angiogenesis • Vascular endothelial growth factor (VEGF) Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  8. Module 11: Cell Proliferation • Platlet-derived growth factor – PDGF • Transforming growth factor b(TGF-b) • Angiogenesis • Vascular endothelial growth factor (VEGF) Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  9. Module 11: Sphingomyellin Signaling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  10. Module 11: Formation and Action of PAMPs Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  11. Module 2: Toll Receptor Signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  12. Module 2: Virus Recognition Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  13. Module 1: Cytokines Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  14. Module 11: TNFα apoptotic signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  15. Module 11: Apoptosis Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  16. Module 11: Figure Bcl-2 family functions Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  17. Module 2: NF-κB activation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  18. Module 11: Macrophage Signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  19. Module 11: Mast Cell Signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  20. Module 11: Cell Proliferation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

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