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Young Investigator Awards

Young Investigator Awards. Early Career Award Symposium October 29, 2010 Jeanne Hardy University of Massachusetts Amherst Department of Chemistry. Projects in the Hardy Lab. Protein engineering to make protein therapeutics. Caspase-7 Caspase-6 CA-GFP Caspase-9 Dengue Virus Protease.

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Young Investigator Awards

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  1. Young Investigator Awards Early Career Award Symposium October 29, 2010 Jeanne Hardy University of Massachusetts Amherst Department of Chemistry

  2. Projects in the Hardy Lab Protein engineering to make protein therapeutics • Caspase-7 • Caspase-6 • CA-GFP • Caspase-9 • Dengue Virus Protease Drugs for neurodegeneration Building an apoptosis reporting mouse to screen for drug toxicity New class of allosteric inhibitors New allosteric sites for treating a global health threat.

  3. Unique structural features of apo caspase-6 Sravanti Vaidya Casp-7 Casp-6 PDB ID: 3K7E 130’s helix 10 Å 90’s helix

  4. Real-time imaging of single cells • FUTURE: • Other colors CA-FP • Other proteases • CA-IRFP for whole mice & zebrafish • + Apoptosis Inducer • - Apoptosis Inducer

  5. Table compiled during my first week here:

  6. http://www.brandeis.edu/givingto/cfr/award-programs.pdf

  7. Awards: Received • The Medical Foundation Smith New Investigator Award • The Beckman Foundation Young Investigator Award • Cottrell Scholar From Research Corporation

  8. Awards: Received Attempted • The Medical Foundation Smith New Investigator Award (Sept 2005) • The Beckman Foundation Young Investigator Award (June 2006) • Cottrell Scholar From Research Corporation (June 2008) • Did not make it through on-campus nomination for Packard 2006 • NSF CAREER* (July 2007) • NIH R01 in Dec 2007 • Packard Foundation Fellowship (July 2008) • HHMI Early Career Award (Jun 2008) • DreyfusTeacher-Scholar Award (Jan 2009) • The Medical Foundation Smith New Investigator Award • The Beckman Foundation Young Investigator Award • Cottrell Scholar From Research Corporation

  9. Contributions to winning a “beauty contest” • Letters of recommendation are very important • My Post Doc Advisor • Well-loved and well-respected, member of NAS • Letter writers from Penn, Princeton & UCSF • Pedigree was good • Unusual background academic/ Industrial • UC Berkeley / Sunesis Pharmaceuticals • Turned down jobs at Princeton, Georgia Tech and U. Illinois: the dept head could say that in his letter • I wrote a draft of the department head’s letter. • Good Proposal

  10. Elements of a Good YI Proposal • Unique idea within my expertise • Some preliminary data, although not required • Wrote to the audience • Good collaborator • Full Professor at UCSD • my prof when I was a grad student • Good images • I followed all the rules applications

  11. An early proposal • Smith • Can you talk to foundation donors.

  12. Thanks! http://people.chem.umass.edu/jhardy/ The Beckman Foundation Young Investigator Award NIH R01 GM080532 NSF FTF CCI CHE-0739227 American Cancer Society IRG Research Corporation Cottrell Scholar Award Center of Excellence in Apoptosis Research Co-PI: K.D. Tremblay NSF IGERT in Cellular Engineering DGE-0654128 Genevieve Abbruzzese  Jun Chu Lindsay Dawson Dan FowlerSumana Ghosh  Amanda Hogan  Kristen Huber  Joachim Moch  Samantha NIcholls Daniel Seeman  Sravanti Vaidya Elih Velazquez  Witold Witkowski  Muslum Yildiz

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