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Retinoblastoma: A Journey Through History and Treatment Advancements

Explore the fascinating history of retinoblastoma, from the terrifying tales of death in the 1600s to modern therapeutic options in the 2000s. Witness the evolution from enucleation in the 1800s to chemotherapy, radiotherapy, and innovative treatments in the 21st century. Learn about the genetic mutations associated with the disease and how presentations have changed over time.

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Retinoblastoma: A Journey Through History and Treatment Advancements

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Presentation Transcript


  1. Retinoblastoma

  2. History • 1600s – scary story of death • 1800s – story of a threatened child blinded but saved by enucleation • 1900s – fairy tale where most children survive and many regain vision • 2000s – Near complete understanding of the disease • Future –

  3. Therapeutic options • 1800s- enucleation • 1990s- chemotherapy • Radiotherapy • Chemoreduction followed by thermo / cryotherapy

  4. Both chromosomes - normal

  5. Germinal mutationOne chromosome- abnormal

  6. Somatic mutationthe other chromosome- abnormal

  7. Presentation

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