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History of Vaccines

History of Vaccines. Variolation : inoculation of smallpox into skin (eighteenth century) Vaccination : Inoculation of cowpox virus into skin (Jenner) Inoculation with rabies virus (Pasteur).

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History of Vaccines

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  1. History of Vaccines • Variolation: inoculation of smallpox into skin (eighteenth century) • Vaccination: • Inoculation of cowpox virus into skin (Jenner) • Inoculation with rabies virus (Pasteur)

  2. Chapter 18, unnumbered figure B, page 510, Reported numbers of measles cases in the United States, 1960–2010. (CDC, 2010) 140 120 Vaccine licensed 100 500,000 80 Reported number of cases 60 450,000 40 400,000 20 350,000 0 300,000 04 2000 01 02 03 05 06 07 08 09 10 Reported number of cases Year 250,000 200,000 150,000 100,000 50,000 0 1960 1965 1975 1985 2000 2010 1970 1990 1995 2005 1980 Year

  3. Vaccines Used to Prevent Bacterial Diseases

  4. Vaccines Used to Prevent Viral Diseases

  5. Vaccines Used to Prevent Viral Diseases

  6. Vaccines for Persons Aged 0–6 Years • Hepatitis B • Rotavirus • DTaP • Haemophilus influenzae type b • Pneumococcal • Inactivated poliovirus • Influenza

  7. Vaccines for Persons Aged 0–6 Years • MMR* • Varicella* • Hepatitis A • Meningococcal * As of 2012 it is not MMRV

  8. Types of Vaccines • Attenuated whole-agent vaccines • MMR vaccine • Inactivated whole-agent vaccines • Salk polio vaccine • Toxoids • Tetanus vaccine

  9. Types of Vaccines • Subunit vaccines • Acellular pertussis • Recombinant hepatitis B • Nucleic acid (DNA) vaccines • West Nile (for horses)

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