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Management of Relapsed / Refractory RCC

Management of Relapsed / Refractory RCC. Sequential Therapy?. Sequencing Targeted Agents in RCC. Targeted Agents: Vertical Inhibition . Targeted Agents: Horizontal Inhibition . Relative Affinities of VEGFR TKIs. TKIs After Immunotherapy: Activity of Sorafenib.

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Management of Relapsed / Refractory RCC

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  1. Management of Relapsed / Refractory RCC

  2. Sequential Therapy?

  3. Sequencing Targeted Agents in RCC

  4. Targeted Agents: Vertical Inhibition

  5. Targeted Agents: Horizontal Inhibition

  6. Relative Affinities of VEGFR TKIs

  7. TKIs After Immunotherapy: Activity of Sorafenib

  8. Several Drugs are Active After Cytokines

  9. Data Supporting Use of Sequential Therapy

  10. Patients With Prior Anti-Angiogenic Tx Achieve Additional Benefit With Sorafenib

  11. Sequential Therapy: Should Second-line Therapy be a Consideration When Selecting First-line Therapy?

  12. Sequential Therapy: Should Second-line Therapy be a Consideration When Selecting First-line Therapy?

  13. Renal Cell Cancer Oral RAD 001 given Daily RECORD -1 Trial Design (n = 416)

  14. Progression-Free Survival by Treatment Central Radiology Review

  15. Overall Survival

  16. Ongoing Clinical Trials in RCC:Sequential Therapies

  17. SWITCH Study to Identify the Best Sequence (N = 540)

  18. RECORD - 3: Phase II Sequence Trial of Everolimus and Sunitinib

  19. Development of Resistance: Angiogenic Escape

  20. Sequential Therapy in RCC

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