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Sydney Brenner

Sydney Brenner. by Andrew Brenner. Early Life. Sydney Brenner was born in 1927 in Germinston, South Africa He discovered the Germinston Public Library (funded by Carnegie) which inspired his thirst for knowledge

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Sydney Brenner

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  1. Sydney Brenner by Andrew Brenner

  2. Early Life • Sydney Brenner was born in 1927 in Germinston, South Africa • He discovered the Germinston Public Library (funded by Carnegie) which inspired his thirst for knowledge • By the age of 15, Sydney was attending university in Johannesburg to study medicine • By 1942, Sydney was studying physics, chemistry, and botany

  3. Career • Sydney remained in South Africa until he received his masters in science • By 1952, Sydney had attended Oxford to work on his PhD in a physical chemistry laboratory • In April 1953, Sydney visited Cambridge to view the proposed model of DNA Watson and Crick had developed

  4. Career • After finishing his PhD, Sydney had returned to South Africa to open up his own research lab • The lab was part of the Physiology Dept. at South Africa Medial School • He had opened up this lab to extend the field of molecular biology • Research at the lab included developing a bacteriophage system to elucidate the genetic code • In 1956, he left to England to continue researching with Crick

  5. Career • In 1961, the Crick, Brenner et al. experiment was performed • This experiment elucidated the triplet codon system for correspondence to amino acids • The experiment also made the existence of frame-shift mutations apparent • The experiment was performed using T4 bacteriophages.

  6. Career • As Max Perutz was retiring in 1979, Sydney was appointed Director of the MRC lab as a successor • During his time as Director, he became interested in DNA sequencing • Became an active proponent in the early stages of the Human Genome Project • In 1986, he took the opportunity to leave his Director’s position to continue doing research

  7. Nobel Prize • Sydney began focusing on using C. elegans as a model organism for research involving animal and specifically neural development in the early 2000s • He chose this worm as a model organism because it is simple to study, easy to grow, and convenient for genetic analysis • In 2002, he won the Nobel Prize for his research on C. elegans with which he shared with H. Robert Horvitz and John Sulston

  8. The End

  9. Sources http://www.nobelprize.org/nobel_prizes/medicine/laureates/2002/brenner-autobio.html http://www.jewishvirtuallibrary.org/jsource/biography/Sydney_Brenner.html http://www.salk.edu/faculty/brenner.html

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