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Corneal Biomechanical Properties in Mexican Population

Corneal Biomechanical Properties in Mexican Population. Alejandro Rivera MD Private Practice. Mexico City. The author has no financial interest in any of the materials described in this poster. Purpose.

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Corneal Biomechanical Properties in Mexican Population

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  1. Corneal Biomechanical Properties in Mexican Population Alejandro Rivera MD Private Practice. Mexico City. The author has no financial interest in any of the materials described in this poster

  2. Purpose The assessment of the biomechanical properties of the cornea is important in the evaluation of patients who will undergone refractive surgery. In the literature there is ambiguity about the influence of age in biomechanical properties. This study will analyze the influence of age in the biomechanical parameters of a Mexican population.

  3. Methods The design was an observational series of patients without history of ocular abnormalities. 1116 eyes of 1116 patients were retrospectively evaluated. The data were taken from files of patients evaluated for refractive surgery. The inclusion criteria were patients of age 20 to 80 years, without ocular or systemic pathology. The Ocular Response Analyzer (Reichert Corporation, Depew, USA) was used to determine the corneal hysteresis (CH) and the corneal resistance factor (CRF). The results were statistically analyzed using the Analise-it for Microsoft Excel program (Version 2.07, Analise-it Software, Ltd. Leeds, UK).

  4. Results Demographic data of the 1116 eyes reported.

  5. Results No significant correlation was found between patient age and the value of corneal hysteresis (Pearson’s correlation: r = - 0,06, 2-tailed p: 0,0321).

  6. Results No significant correlation was found between patient age and the value of corneal resistance factor (Pearson’s correlation: r = - 0,00, 2-tailed p: 0,9235).

  7. Conclusion There is discrepancy about the influence of age on the corneal biomechanical variables. Although some articles demonstrate a negative correlation between age and corneal resistance factor and corneal hysteresis (1,2) other studies report the opposite (3). As shown in the results of the present study no correlation was found between age and corneal hysteresis and corneal resistance factor. Maybe this reflects the different influences of age on the biomechanics of the cornea. There is an increase in the stiffness of the corneal tissue that could be related to the additional age-related nonenzymatic cross-linking affecting the stromal collagen fibrils (4). On the other hand, there are age-related changes in ultrastructural collagen fibril orientation and dimensions that could decrease the strength of the cornea (5).

  8. References • Kamiya K, Shimizu K, Ohmoto F. Effect of aging on corneal biomechanical parameters using the ocular response analyzer. J Refract Surg 2009; 25: 888-893. • Kotecha A, Elsheikh A, Roberts CR, Zhu H, Garway-Heath DF. Corneal thickness- and age-related biomechanical properties of the cornea measured with the ocular response analyzer. Invest Ophthalmol Vis Sci 2006; 47:5337-5347. • Kamiya K, Hagishima M, Fujimura F, Shimizu K. Factors affecting corneal hysteresis in normal eyes. Graefes Arch Clin Exp Ophthalmol 2008; 246: 1491-1494. • Elsheik A, Wang D, Brown M, Rama P, Campanelli M, Pye D. Assessment of corneal biomechanical properties and their variation with age. Curr Eye Res. 2007; 32: 11-19. • Daxer A. Age-related corneal biomechanical changes. J Cataract Refract Surg; 2008: 34: 715.

  9. Acknowledgment The author is grateful to Magdalena Fabila MD for her support in the evaluation of the data of this study.

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