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Chromeleon 7.2

Chromeleon 7.2 . ACS New Orleans Thermo Fisher Scientific Larry G. West. Meet New Charlie Chromeleon. Chromeleon Goes MS!. Enterprise architecture Unparalleled ease-of-use Multi-vendor instrument control Comprehensive compliance tools. >30 years of MS experience

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Chromeleon 7.2

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  1. Chromeleon 7.2 ACS New Orleans Thermo Fisher Scientific Larry G. West

  2. Meet New Charlie Chromeleon

  3. Chromeleon Goes MS! • Enterprise architecture • Unparalleled ease-of-use • Multi-vendor instrument control • Comprehensive compliance tools • >30 years of MS experience • Leading-edge MS portfolio • Unparalleled MS application expertise • First CDS integrating MSinto routine and quantitative workflows

  4. CHROMELEON 7.2 Highlights

  5. Ease of use:operational simplicity™

  6. Chromeleon® 7 - Operational Simplicity™ • Operational Simplicity™ is the core design principle • Major design rules: • Minimize number of steps needed to perform any task • Make all steps easy to understand and easy to use • Minimize time needed to perform any task • Three major features using Operational Simplicity™: • Modern user interface • Peak detection and integration tools • eWorkflows

  7. Easy to Use with Powerful Capabilities Ease of use:User Interface

  8. Console - Easy Access to Data Navigation Pane Category Bars

  9. Console - Easy Access to Data Integrated sequence editor MiniPlots™

  10. Console – Easy Access to Instruments via ePanels Immediate access to Audit Trail and Queue Provides access to all instruments on the network ePanels are auto-generated for each instrument.

  11. Chromatography Studio - All Details of an Experiment Ribbon Navigation Pane Category Bars

  12. Dynamic Data Linking Cobra™ Detection Algorithm / SmartPeaks™ Data Processing

  13. Data Dynamic Linking and Updating - 1 Likely cause is this outlier point. To investigate, double click point and associated chromatogram is automatically displayed Calibration has failed specification

  14. Data Dynamic Linking and Updating - 2 Integration is incorrect

  15. Data Dynamic Linking and Updating - 3 Integration is corrected

  16. Data Dynamic Linking and Updating - 4 Calibration point is recalculated

  17. Data Dynamic Linking and Updating - 5 Calibration line fitting is recalculated Calibration now passes specification

  18. Even More Interactivity in Chromeleon 7.2 • Current behaviour – clicking on different peaks brings up the associated calibration curve

  19. Even More Interactivity in Chromeleon 7.2 • New Link Panes option shows curves for all peaks in view

  20. EASE OF USE: SMART PEAKS

  21. SmartPeaks – A Revolution in Ease of Use • There are many ways to integrate unresolved peaks Is this what we want? Is this what we want?

  22. SmartPeaks™ Integration Assistant 1. Activate SmartPeaks Wizard 3. Select the Integration You Want 2. Select Area of Interest

  23. SmartPeaks™ Integration Assistant And Your Integration Is Done!

  24. The Ultimate in Operational Simplicity™ Ease of use: eWorkflows™

  25. eWorkflows • eWorkflows to boost lab productivity - typically 30-50% time savings • Applies to all laboratories, for example: • QA/QC laboratories • Method development laboratories • Research & Development laboratories • Walk-up instrument workflows • Built-in Templates for Key Pharma Applications • GPC • ICH Method Validation • Dissolution Testing • Content Uniformity Testing

  26. eWorkflow for a Regulated USP/EP Method 3. Sequence is created and can be immediately run 1. Choose eWorkflow, Select Instrument, and Click “Launch” 2. Enter Number of Samples and Start Position

  27. From Sample to Result in the Shortest Time Possible eWorkflow for a Regulated USP/EP Method This eWorkflow also: • Processes all data • Calculates all results

  28. “A Picture Speaks a Thousand Words” Ease of use:Data Visualization

  29. Interactive Charts • Visualize all your dynamically linked data in interactive charts Chart shows results of selected peak Selected injection is indicated in the chart

  30. Data Mining Tools • Queries can be executed to find any injection, or group of injections. • Search fields include any sample criteria or any calculated result! Example: • Find all Standards • Injected on HPLC_System_13 • During the previous 6 months • Using Instrument Method TM122 • With a peak name containing Methyl

  31. Data Mining Tools Search criteria are entered into a simple interface….

  32. Data Mining Tools Query results are immediately displayed as a Virtual Sequence

  33. Data Mining Tools • Example: Samples injected over a 3 year period for a stability study • Samples can be located, in this case Lot Number is used • Once the data is located it can be compared as if it belongs to the same sequence:

  34. Data Mining Tools • Using Excel-like functionality the report table can immediately indicate a Pass or Fail result:

  35. Data Mining Tools • The data can also be viewed graphically in charts: Here the active ingredient is shown degrading over time

  36. Data Mining Tools • The data can also be viewed graphically in charts: And the Relative Area of the impurity over the same time period

  37. Example: Column Performance • Charting column performance throughout a sequence, or multiple sequences over a period of time:

  38. Reporting Tools

  39. Spreadsheet Based Reporting • The Excel-like report environment is both familiar and intuitive. • If Excel is used for additional calculations they can be included in Chromeleon. • No data transcription or export to Excel is required. • Results are generated instantly.

  40. Spreadsheet Based Reporting Excel-like formulae can be included for custom calculations In this case the operator has configured a report to flag out of specification results.

  41. Intelligent Run Control

  42. Intelligent Run Control • Chromeleon 7.2 automates injection decisions, based on previous results and chromatographic specifications • Improves analytical efficiency • Improve or standardise product quality • Reduces solvent & analyte use • Reduces results review process

  43. Intelligent Run Control • Component Carry Over • TestIs area of Peak A < 5 mAU/min for a Blank Injection? • Pass Action continue • Fail Action add Blank injection to sequence, and inject • Compare against Reference Chromatogram • ActionRef Chrom – Default Channel = Subtracted • TestIs Subtracted number of peaks < 1? • Pass Action continue • Fail Action abort

  44. Intelligent Run Control • Example of an Unconditional Action • Set the desired action and then set properties for that action

  45. Instrument Control

  46. Instrument Control • Chromeleon 7 can control Thermo Scientific LC, GC and IC. • Chromeleon 7 can control 3rd Party LCs and GCs • Agilent 1100, 1120, 1200, 1220, 1260, 1290, G1888, 5890, 6850, 6890, 7890 • Waters Acquity, Alliance • Shimadzu LC and GC • Perkin Elmer 200 LC and Clarus/XL GC • Chromeleon 7.2 controls 370+ instruments.

  47. Networking Capabilities: Chromeleon Enterprise Environment

  48. Key Features for an Enterprise Environment • Networking capabilities • Central data storage • Choice of database • Acquiring data to a central data vault • Network failure protection • Multiple Instrument Control • Instruments from different vendors • AND Thermo Scientific MS • Centralized Administration • License management, license server • User management • Security • User management, access control • Electronic signatures

  49. Compliance:CONTROLLED ACCESS

  50. Compliance • Ensure Compliance in your laboratory using: • Comprehensive user management tools • Fully automated hardware and software qualification • Integrated System Suitability Tests (SST) • Audit Trails (instrument & data) to trace all actions done in the software • History views of objects to track changes and easily revert to prior versions • Integrated Electronic Signatures for 21 CFR Part 11b compliance

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