Bonner, 1998 (arm C)

1. Supplemental Figure 3. Individual and pooled median overall survivals with corresponding 95% confidence interval in study arms, according to the patterns of CCT: CCT-, CCCT and SCCT. Hazard ratios of CCCT/SCCT to CCT are shown at the bottom of the figure. Median overall survival (months) 0 10 20 30 40 50 n=32 Bonner, 1998 (arm C) Komaki, 1997 (arm 2) n=82 Kubota, 2000 n=74 Lee SW, 2003 n=161 Curran, 2011 (arm 3) n=200 Furuse, 1995 n=65 Ichinose, 2004 n=70 n=156 Furuse, 1999 Curran, 2011 (arm 2) n=200 CCT- Kim, 2005 n=135 Lee, 1996 n=79 Yoshizawa, 2003 n=30 Fukuda, 2007 n=48 Bradley, 2010 n=44 n=42 Kiura, 2003 Segawa, 2010 n=100 n=41 Jeremic, 1998 Segawa, 2010 n=100 Jeremic, 2005 n=64 n=49 Cho, 2009 Total n=1,772 17.9(95%CI: 16.1-19.9) Jain, 2009 n=67 Byhardt, 1995 n=42 Le Péchoux, 1996 n=34 Choy, 2000 n=43 Ratanatharathorn, 2001 n=30 Rusu, 2007 n=57 Albain, 2002 n=50 Park, 2003 n=54 Belani, 2005 (arm 3) n=92 CCCT Lau, 2001 n=34 Segawa, 2000 n=50 Iwasaki, 2006 n=46 Yamamoto, 2010 (arm B) n=152 Yamamoto, 2010 (arm A) n=153 Choy, 1998 n=40 Govindan, 2011 (arm A) n=48 CCT+ Yamamoto, 2010 (arm C) n=156 Albain, 2009 (arm 2) n=194 Sakai, 2004 n=33 Ohyanagi, 2009 n=50 Oshita, 2010 n=35 19.1 (95%CI: 17.2-21.2) Total n=1,460 Bastos, 2010 n=32 Fournel, 2005 n=100 SCCT Mostafa, 2007 n=32 Gandara, 2003 n=83 19.0 (95%CI: 14.6-24.7) Total n=247 Hazard ratio of CCCT to CCT- = 0.94 (95%CI: 0.81-1.09), p= 0.424 Hazard ratio of SCCT to CCT- = 0.94 (95%CI: 0.71-1.26), p= 0.694