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My Omics Epic (a journey of learning, collaboration, innovation and technology)

My Omics Epic (a journey of learning, collaboration, innovation and technology) Thomas R. Sutter, Ph.D. Professor of Biology and Chemistry W. Harry Feinstone Chair of Excellence in Molecular Biology. Research and Networking February 27, 2019 University of Memphis. Topics.

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My Omics Epic (a journey of learning, collaboration, innovation and technology)

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  1. My Omics Epic (a journey of learning, collaboration, innovation and technology) Thomas R. Sutter, Ph.D. Professor of Biology and Chemistry W. Harry Feinstone Chair of Excellence in Molecular Biology Research and Networking February 27, 2019 University of Memphis

  2. Topics • Omics in the Pre-Human Genome Era (April, 2003) • Differential Hybridization (How sets of genes affect cell differentiation; cancer causation and prevention) • Four people, $250,000, 3 years • All things Omics (computational sciences and data integration) • Microarray and Metabolomics • Eight people, $50,000, 3 months (plus 2 years of data analysis!) Kennedy, L.H., Sutter, C.H., Carrion, S.L. Tran, Q.T., Bodreddigari, S., Kensicki, E., Mohney, R.P., and Sutter, T.R. 2013. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation. Toxicol. Sci. 132: 235-49. Sutter, C.H., Olesen, K.M., Bhuju, J., Guo, Z and Sutter, T.R. 2018. The AHR regulates metabolic reprogramming to promote SIRT1-dependent keratinocyte differentiation. J. Invest. Dermatology, in press [E-pub ahead of print], doi:10.1016/j.jid.2018.10.019. Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta TR Sutter, K Guzman, KM Dold, WF Greenlee Chemical Industry Institute of Toxicology, Research Triangle Park, NC Science 18 Oct 1991: Vol. 254, Issue 5030, pp. 415-418 DOI: 10.1126/science.1925598

  3. Central Dogma: Sensitive Scalable Comprehensive Proteomics Genomics - Component proteins/levels - Location, modifications, interactions - Function and activity - Structure (sequence) - Regulation - Function: expression in all of its forms Metagenomics (microbiome) Metabolomics - Community of microorganisms - Changes with state (e.g. disease) - Interaction with metabolome, epithelial barrier, immune system - Large scale small molecule - Metabolites: biochemistry - Flux: metabolism

  4. University of Memphis (6 dept) UTHSC (7 dept) Johns Hopkins University University of Pittsburgh Dartmouth Vanderbilt Fox Chase Cancer Center University of Nebraska NYU AHR researchNrf2 research NIH ES017014 (10) NIH CA39416 (15) GE (4) Roche Biosciences (3) Dow (3) NCI-N01-CN-95114 (3) University of Pennsylvania University of Dresden, Germany General Electric Metabolon Roche Bioscience, CA Roche, United Kingdom F. Hoffman-La Roche, Switzerland Dow Chemical NIH: NIEHS, NTP, NCI; NCTR, ORNL CYP1B1 researchOther Total > $15M NIH ES08148 (5) MRC (4) DMAD-17-03-0229 (5) JHU CAAT (2) DOD BC022345 (4) NIH U01AA13515 (5) Sutter Lab Collaborations at UM (30 omic publications)

  5. Thank you

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