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LUNG TRANSPLANTATION. Overall. 1554. 1416. 1508. 1413. 1408. 1341. 1337. 1204. 1069. 902. 686. 408. 185. 80. 15. 47. 13. NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE. * Numbers may be low due to delayed reporting.
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LUNG TRANSPLANTATION Overall
1554 1416 1508 1413 1408 1341 1337 1204 1069 902 686 408 185 80 15 47 13 NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE * Numbers may be low due to delayed reporting.
NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND LOCATION * Numbers may be low due to delayed reporting.
1985-1996 1997-2001 AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS BY ERA
LUNG TRANSPLANTATIONActuarial Survival (1990-2000) Double lung: 1/2-life = 4.9 Years; Conditional 1/2-life = 7.9 Years Single lung: 1/2-life = 3.7 Years; Conditional 1/2-life = 5.9 Years All lungs: 1/2-life = 4.1 Years; Conditional 1/2-life = 6.5 Years
LUNG TRANSPLANTATION Adult Recipients
ADULT LUNG TRANSPLANTATION: Indications(1995-2001) Single Lung Transplants Bilateral/Double Lung Transplants
ADULT LUNG TRANSPLANTATIONActuarial Survival by Era (1988-2001) Survival comparisons by era 1988-1992 vs. 1993-1997: p = 0.007 1988-1992 vs. 1998-2001: p < 0.0001 1993-1997 vs. 1998-2001: p = 0.003
ADULT LUNG TRANSPLANTATIONActuarial Survival by Age Group(1990-2001) Survival comparisons by age group 18-34 vs. 50-64: p < 0.0001 18-34 vs. 65+: p = 0.0009 35-49 vs. 50-64: p < 0.0001 35-49 vs. 65+: p = 0.0004
ADULT LUNG TRANSPLANTATIONActuarial Survival By Diagnosis(1990-2001)
ADULT LUNG TRANSPLANTATIONActuarial Survival By Procedure Type Diagnosis: Alpha-1 Antitrypsin Deficiency(1990-2001) P = 0.03
ADULT LUNG TRANSPLANTATIONActuarial Survival by Procedure Type Diagnosis: Emphysema/COPD(1990-2001) P < 0.0001
ADULT LUNG TRANSPLANTATIONActuarial Survival by Procedure Type Diagnosis: IPF(1990-2001) P = 0.2
ADULT LUNG TRANSPLANTATIONActuarial Survival by Procedure Type Diagnosis: PPH(1990-2001) P = 0.4
ADULT LUNG TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityIn Descending Order of Magnitude N=5,242
ADULT LUNG TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityIn Descending Order of Magnitude N=5,242
ADULT LUNG TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=5,242
ADULT LUNG TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=5,242
ADULT LUNG TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=5,242
ADULT LUNG TRANSPLANTS (1996-2001)Factors Not Significant for 1 Year Mortality • Steroid dependency • Ischemia time • % Predicted FeV1 • % Predicted FVC • Transfusions • Diabetes • Weight (donor) • Height (donor) • Donor clinical infection • Donor history of hypertension • Donor given steroids
ADULT LUNG TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityIn Descending Order of Magnitude N=3,098
ADULT LUNG TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityIn Descending Order of Magnitude N=3,098
ADULT LUNG TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=3,098
ADULT LUNG TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=3,098
ADULT LUNG TRANSPLANTS(April 1994-December 1996)Risk Factors for 5 Year MortalityContinuous Factors N=3,098
ADULT LUNG TRANSPLANTS(April 1994-December 1996)Factors Not Significant for 5 Year Mortality • Steroid dependency • Ventilator • Ischemia time • % Predicted FeV1 • % Predicted FVC • Transfusions • Diabetes • Weight (donor) • Height (donor) • Donor clinical infection • Donor history of hypertension • Donor given steroids
ADULT LUNG TRANSPLANTS (April 1994-December 1996)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearIn Descending Order of Magnitude N=2,285
ADULT LUNG TRANSPLANTS (April 1994-December 1996)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearContinuous Factors N=2,285
ADULT LUNG RECIPIENTSFunctional Status(April 1994 – December 2001)
ADULT LUNG RECIPIENTSEmployment Status(U.S.: April 1994 – December 2001)
ADULT LUNG RECIPIENTS: Rehospitalization Post-transplant(April 1994 - December 2001)
ADULT LUNG RECIPIENTS Induction ImmunosuppressionFor follow-ups between October 1999 and December 2001
ADULT LUNG RECIPIENTSMaintenance Immunosuppression At Any Time During Follow-up PeriodFor follow-ups between October 1999 and December 2001
ADULT LUNG RECIPIENTSMaintenance ImmunosuppressionAt Time of Follow-upFor follow-ups between October 1999 and December 2001
ADULT LUNG RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001 1 Year Follow-up (N = 1,177) 5 Year Follow-up (N = 547)
ADULT LUNG RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001
POST-LUNG TRANSPLANT MORBIDITYFor Adult Recipients(April 1994-December 2001)
Freedom from Bronchiolitis Obliterans For Adult Lung Recipients(April 1994-December 2000)
Freedom from Renal Dysfunction*For Adult Lung Recipients(April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant
MALIGNANCY POST-LUNG TRANSPLANTATION FOR ADULTSCumulative Incidence for Survivors(April 1994-December 2001)
Freedom from MalignancyFor Adult Lung Recipients(April 1994-December 2000)
ADULT LUNG TRANSPLANT RECIPIENTS: Cause Of Death(1982-2001) Timing of Death
ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 0-30 Days Year of Transplant
ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 31 Days – 1 Year Year of Transplant
ADULT LUNG TRANSPLANTS RECIPIENTS:Cause of Death by Era: Deaths in >1 Year – 3 Years Year of Transplant