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Rick Yost Mass Spectrometry and Ion Mobility Spectrometry Analytical Chemistry

Other UF Research with ES CSTC and Space Biotechnology Applications. Rick Yost Mass Spectrometry and Ion Mobility Spectrometry Analytical Chemistry University of Florida. UF Facts

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Rick Yost Mass Spectrometry and Ion Mobility Spectrometry Analytical Chemistry

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  1. Other UF Research with ES CSTC and Space Biotechnology Applications Rick Yost Mass Spectrometry and Ion Mobility Spectrometry Analytical Chemistry University of Florida

  2. UF Facts • UF offers more academic programs on one campus than any other University (tied with Ohio State and Minnesota) • 43,500 students on campus, the 6th largest university in US - (10,000 grad students, 3,000 professional, 31,500 undergrads) • 4,000 faculty • $300M in research grants/year • 8th among all universities in royalty income • 8th among all universities in number of U.S. patents awarded

  3. Department of Chemistry UF Chemistry Facts • among the top 8 PhD-granting Chemistry departments in the US • 12th in total research spending for Chemistry • 1st in industrial funding for Chemistry • 46 tenured or tenure-track faculty • 7 teaching and research support faculty • 250 graduate students • 85 postdoctoral and other scientific associates • 42 staff members

  4. UF Graduate Program in Chemistry UF http://www.acs.org/education/cpt/cptsr01.html

  5. Analytical Chemistry UF Analytical Chemistry Facts • among the top four Analytical Chemistry programs in the US • 8 tenured faculty • 2 teaching and research support faculty • 81 graduate students • 20 postdoctoral associates

  6. Yost Research Group • Analytical chemistry • Instrumentation development and applications • High-performance mass spectrometry • High-field ion mobility spectrometry (FAIMS) • Over $5M in grants ($1.2M from NASA) • Close collaboration with industrial partners • Over $2B worth of analytical instruments sold based upon these partnerships

  7. NASA Projects Completed Projects • NASA-Ames/KSC, Finnigan - Mass Spectrometric Automation and Artificial Intelligence for NASA Manned Space Environments • NASA/Dynacs - Design of a Miniature Ion Trap Mass Spectrometer for Launchpad Monitoring • FSGC/Dynamac - Miniature Mass Spectrometer for Biological and Environmental Monitoring • FSGC - Laser Microprobe Mass Spectrometry for Mapping Compounds in Intact Tissue

  8. NASA Projects Pending Projects • UF/ES CSTC/Stennis – New Analytical Methods and Instrumentation for Monitoring Plant Stress • UF/SABRE – Monitoring Plant Stress for Plants Grown under Martian Atmospheric Conditions • UF/SABRE –Metabolomics (Metabolic Profiling) of Plant Stress by LC/MS/MS • UF/UCF-Development of a Virtual Range to Validate Safety Criteria of Current and 2nd and 3rd Generation Space Vehicles (Fieldable Sensors)

  9. Technology for Environmental Science and Biotechnology Applications • High-performance mass spectrometry • Tandem mass spectrometry (MS/MS) • Laser microprobe MS/MS • Fourier-transform mass spectrometry (FTMS) • High-field ion mobility spectrometry (FAIMS) • programmable multi-component sensors (small, low-power) • remarkably high sensitivity and selectivity • similar to IMS systems used for explosives detection • similar to the IMS system (VOA) on board the International Space Station

  10. Tandem mass spectrometry (MS/MS) (Triple Quadrupole) Tandem-in-Space Tandem-in-Time (Quadrupole Ion Trap) vs.

  11. Signal S/N Chemical Noise Tandem mass spectrometry (MS/MS) • Enhance selectivity by combining complimentary techniques • Number of Stages = • GC • GC/MS • GC/MS/MS • GC/MS/MS/MS

  12. Laser microprobe MS/MS Laser Ion Trap Ion Source Sample Probe

  13. Map trace compounds at low ppm levels in intact tissue – drugs, metabolites, biomarkers • Spatial resolution 100μm, potentially 10μm

  14. R ~ 10,000 @ m/z 28 Fourier-Transform mass spectrometry (FTMS) • Ultra-high resolution (105 @ m/z 100) • Exact mass for empirical formulae • MS/MS for structure elucidation • 1/10 the size and weight of conventional FTMS systems

  15. Conventional IMS To Detector FAIMS apparatus Ion Mobility Spectrometry • Measure size/charge of ions at atmospheric pressure • IMS widely used for explosives, chemical agent detection, VOA on ISSS • FAIMS offers far higher sensitivity and selectivity • FAIMS has potential for miniaturization

  16. High-field Ion Mobility Spectrometry (FAIMS)

  17. Projected Partnerships • Laser microprobe MS/MS • Thermo Finnigan Fourier-transform MS • Siemens Automation High-field ion mobility spectrometry (FAIMS) • Ionalytics, a spin-off from NRC Canada • Sionex, a spin-off fromCharles Stark Draper Lab at MIT Applications (and/or instrumentation) • UF, NASA research centers • North Carolina partners

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