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The Use of Animals in Research Is a Privilege We Wish to Retain

The Use of Animals in Research Is a Privilege We Wish to Retain. Animal Welfare Versus Animal Rights. How are Animal Welfare Concerns Reported?. Regulatory Oversight. APHIS 1 : Animal Welfare Act NIH: Guide for the Care and Use of Laboratory Animals

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The Use of Animals in Research Is a Privilege We Wish to Retain

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  1. The Use of Animals in Research Is a Privilege We Wish to Retain Animal Welfare Versus Animal Rights How are Animal Welfare Concerns Reported?

  2. Regulatory Oversight • APHIS1: Animal Welfare Act • NIH: Guide for the Care and Use of Laboratory Animals • AAALAC2: Ongoing Accreditation Inspections • Inspectors Select Animals and their Protocols for Review • Their Review is Based on What is Written • Animal and Plant Health Inspection Service (USDA) • Association for Assessment and Accreditation of Laboratory Animal Care

  3. Animal Protocols A Research Facility Must Have an Institutional Animal Care and Use Committee (IACUC) An IACUC Approved Animal Protocol Is Required Before Any Animal Experiments Can Be Requested Or Begun New NIH Just In Time Process

  4. Who Can Apply for Animal Protocols at TSRI ? Research staff (Professors) Research Associates, with the Professor taking responsibility if an appointment to the research staff is pending on funding The applicant must have completed all appropriate training

  5. Animal Protocol Review Protocol Review Full Committee Review – Monthly Designated Reviewer – Ongoing Review Depends on Protocol Content The Steps Involved Forms, Instructions, Standard Protocols Booklet in the new IACUC Office in the 3366 Building. A website is coming soon!

  6. The Assurance Declaration to be Signed by the Institutional Official once the Protocol is approved by the IACUC

  7. The Title Page Boxes to be checked may signal need for full committee review Collaboration within or out of TSRI (to be explained in the protocol)

  8. List the number of animals requested. • Provide the experimental plan and use of procedures with scientific justification. • Justify the species and number of animals requested. The use of statistics is recommended by the PHS to determine group size.

  9. Provide information on veterinary care (standard statement) Protocols involving surgery need veterinary consultation during preparation

  10. Measures to minimize pain and distress including post-operative monitoring and analgesia Euthanasia Must conform with the AVMA 2000 Panel Report on Euthanasia or be justified scientifically

  11. Alternatives Statement for Painful or Distressful Procedures: Include data bases searched (Medline and Agricola a minimum), key words, date of search, must consider the 3 R’s: reduction, refinement, and replacement Library/resources/animal alternatives web site No unnecessary duplication must also be assured

  12. General description of the project and its scientific justification Scientific American style, so lay people on the Committee can understand Can modify the summary statement from the grant

  13. Antibody production CFA alternatives statement Use of Standard Protocols Booklet (see example)

  14. HANDLING (CODE: MH)A mouse should be picked up by grasping its tail close to the body, the loose skin near the nap of the neck or by gently closing your hand around the body. To restrain a mouse for examination and injections, grasp the loose skin at the nape of its neck between your thumb and index finger and place its tail between the fourth and fifth fingers. Be careful not to impede respirations or to grab the tail anywhere but close to the base; remember that the tail can be damaged if excess pressure is applied, or if grasped in areas distal to the base.Mother mice normally move their offspring by picking them up by the nape of the neck. Pain and/or distress level II.

  15. Must provide detailed protocols for any procedures not included in or at variance with the Standard Protocols Booklet Need to include post procedure monitoring, care, and analgesia

  16. List all substances administered to animals including dose, route, infectious and radioactive compounds Attach IBC, EH&S, radiation approvals as needed Biological products, consider contamination List any work requested outside the animal facility

  17. Required training varies with role in protocol

  18. Training continued List work done by DAR

  19. Signature of PI taking responsibility for following the protocol Remember, the animal protocol must cover all animal work requested in the grant When complete, a copy of the grant must be submitted to be kept on file with the protocol

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